Distribution and Excretion of Mercury Compounds in Rats over a Long Period after a Single Injection
Distribution and Excretion of Mercury Compounds in Rats over a Long Period after a Single Injection
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单次注射后较长时间内汞化合物在大鼠体内的分布和排泄
DOI：
10.1111/j.1600-0773.1968.tb00446.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
U. Ulfvarson
中科院分区：
文献类型：
--
作者：
Å. Swensson;U. Ulfvarson
Rats were given single subcutaneous injections of methyl mercuric hydroxide, mercury (II) nitrate and phenyl mercuric hydroxide. The elimination of the compounds and the concentration in the organs at different times were followed by means of isotope techniques, for almost 6 months. The rate of excretion changes during the observation period. A calculated biological half-life therefore will be different from time to time. If the elimination during the first 9 days is considered the half-life is 5 days for mercury (II) nitrate and phenyl mercuric hydroxide and 16 days for methyl mercuric hydroxide. After this the excretion rate becomes slower and slower. The distribution in the organs varies during the first part of the period. The blood concentration decreases rapidly for all compounds, while the concentrations in the kidneys increases and reaches a maximum after some days. The same holds true for the brain and testis when mercury (II) nitrate and methyl mercuric hydroxide are considered. The elimination from the kidneys, the brain and the testes is slower than from other organs for all compounds. The concentrations in different parts of the brain are rather similar, though somewhat higher concentration in lobus olfactorius is indicated.
