Epidermal powder immunization of mice and monkeys with an influenza vaccine
Epidermal powder immunization of mice and monkeys with an influenza vaccine
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DOI：
10.1016/s0264-410x(03)00175-0
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发表时间：
2003-06-20
期刊：
影响因子：
5.5
通讯作者：
Payne, LG
中科院分区：
文献类型：
--
作者：
Chen, DX;Endres, R;Payne, LG
用流感疫苗和佐剂如QS-21、LTR 72或霍乱毒素的表皮粉末免疫（EPI）在小鼠中引起增强的血清和粘膜抗体应答。具有与人类相似的免疫系统和皮肤结构的恒河猴用于进一步评价EPI后流感疫苗的免疫原性。用流感疫苗和QS-21佐剂的恒河猴EPI引起的血清血凝抑制（HI）滴度显著高于通过EPI或通过使用针和注射器的肌内（IM）注射施用的单独抗原。在不存在QS-21的情况下，EPI和IM注射在猴中引起相当的HI滴度。本研究表明，EPI是一种有前途的人用疫苗接种技术，QS-21可增强联合接种流感疫苗的免疫原性。(C)2003爱思唯尔科技有限公司版权所有。
Epidermal powder immunization (EPI) with an influenza vaccine and an adjuvant such as QS-21, LTR72, or cholera toxin elicited augmented serum and mucosal antibody responses in mice. Rhesus macaques, which have an immune system and skin structure similar to humans, were used to further evaluate the immunogenicity of the influenza vaccine following EPI. EPI of rhesus macaques with an influenza vaccine and QS-21 adjuvant elicited significantly higher serum hemagglutination inhibition (HI) titers than antigen alone administered by EPI or by intramuscular (IM) injection using a needle and syringe. In the absence of QS-21, EPI and IM injection elicited comparable HI titers in the monkeys. This study suggests that EPI is a promising technique for administering human vaccine and that QS-21 augments the immunogenicity of co-administered influenza vaccine. (C) 2003 Elsevier Science Ltd. All rights reserved.