Dopamine and cognitive functioning in de novo subjects with Parkinson's disease: Effects of pramipexole and pergolide on working memory
Dopamine and cognitive functioning in de novo subjects with Parkinson's disease: Effects of pramipexole and pergolide on working memory
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DOI：
10.1016/j.neuropsychologia.2009.01.039
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发表时间：
2009-04-01
期刊：
影响因子：
2.6
通讯作者：
Carlesimo, Giovanni Augusto
中科院分区：
文献类型：
--
作者：
Costa, Alberto;Peppe, Antonella;Carlesimo, Giovanni Augusto
很少有研究探讨多巴胺能治疗与帕金森病（PD）患者工作记忆功能的关系。本研究的目的是探讨培高利特（一种D-1 + D-2受体激动剂）和普拉克索（一种D-2 + D-3受体激动剂）的药物治疗对PD患者在视觉空间、视觉对象和言语WM任务中的表现的影响。参与者包括19名“新发”PD患者和13名健康对照（HC）。实验任务由n-back范式组成，包括言语、视觉-对象或视觉-空间刺激。PD患者执行了两次任务：在18-24小时的治疗结束后，在给予培高利特（9名患者）或普拉克索（10名患者）后。hc只执行了一次任务，没有给药。根据他们在“关闭”和“打开”治疗条件下的表现，9名PD患者被分为低表现组（即，在n-back范式下的表现低于实验样本的中位数）和高表现组（即，表现高于中位数）。一名PD患者被排除在分析之外，因为他的表现模式清楚地表明他是一个异常值。在表现不佳的PD患者中，同时使用培高利特和普拉克索可提高所有WM任务的准确性。在表现良好的患者中没有发现药物的作用。本研究结果表明，刺激多巴胺能受体可能通过调节额纹状体回路的活动来改善PD患者的高水平WM过程。2009爱思唯尔有限公司版权所有。
Very few studies have investigated the relationship between dopaminergic therapy and working memory (WM) functioning in Parkinson's disease (PD) patients. The aim of the present study was to explore the effects of pharmacological treatment with pergolide (a D-1 + D-2 receptor agonist) and pramipexole (a D-2 + D-3 receptor agonist) on performance in visual-spatial, visual-object, and verbal WM tasks in PD patients. Participants included 19 "de novo" PD patients and 13 healthy controls (HC). The experimental task consisted of an n-back paradigm with verbal, visual-object, or visual-spatial stimuli. PD patients performed the task twice: after 18-24 h of therapy wash-out and after administration of pergolide (nine patients) or pramipexole (ten patients). HCs performed the task only once, without drug administration. Depending on how they performed in the "Off' and "On" therapy conditions, the nine PD patients each were classified into groups of low performers (i.e., performance on the n-back paradigm was below the median value of the experimental sample) and high performers (i.e., performance was above the median value). One PD patient was excluded from the analysis because his performance pattern clearly revealed that he was an outlier. In the low performer PD patients, administration of both pergolide and pramipexole improved accuracy on all WM tasks. No effect of the drugs was found in the high performer patients. The results of the present study show that stimulation of dopaminergic receptors improves high-level WM processes in PD patients, possibly by modulating activity in frontal-striatal circuits. (C) 2009 Elsevier Ltd. All rights reserved.