Enhanced cocaine self-administration in adult rats with adolescent isolation experience
Enhanced cocaine self-administration in adult rats with adolescent isolation experience
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DOI：
10.1016/j.pbb.2005.11.007
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发表时间：
2005-12-01
影响因子：
3.6
通讯作者：
Ma, L
中科院分区：
文献类型：
--
作者：
Ding, YJ;Kang, L;Ma, L
人们普遍认为，早期的环境影响可能会影响成年动物的行为及其对精神药物的反应。隔离饲养动物是研究早期生活压力和了解某些神经和精神疾病发展的相关范例。本研究评价了青少年隔离对成年大鼠静脉注射可卡因自我给药的影响。雄性Sprague-Dawley大鼠从出生后第22天饲养至第55天，单独饲养（隔离）或以每笼4只为一组饲养（分组）。然后，训练大鼠进行可卡因自我给药。我们的研究结果表明，孤立和分组大鼠获得稳定的可卡因自我管理在5天的自我管理训练。隔离组大鼠按杆次数和可卡因输注次数均显著多于分组组。尤其是隔离组大鼠的误操作次数明显多于分组组。此外，与分组大鼠相比，隔离大鼠可卡因的相互强化间隔显著缩短。这些结果表明，青少年隔离经验的大鼠增强可卡因自我管理行为。(C)2005年由Elsevier Inc.出版
It is widely accepted that early environmental influences may affect the behavior of adult animals and their responses to psychotropic drugs. Rearing animals in isolation is a relevant paradigm for studying early life stress and for understanding the development of certain neurological and psychiatric diseases. The present study evaluated the effect of adolescent isolation on intravenous cocaine self-administration in adult rats. Male Sprague-Dawley rats were raised from postnatal day 22 to 55 either alone (isolated) or in groups of four per cage (grouped). Then, rats were trained for cocaine self-administration. Our results showed that both isolated and grouped rats acquired stable cocaine self-administration during 5 days of self-administration training. Numbers of both lever presses and cocaine infusions in isolated rats were significantly more than those in grouped rats. Especially, numbers of incorrect lever presses in isolated rats were significantly more than those in grouped rats. In addition, the intervals of inter-reinforcement for cocaine in isolated rats were significantly shorter as compared with grouped rats. These results indicate that rats with adolescent isolation experience have enhanced cocaine self-administration behavior. (C) 2005 Published by Elsevier Inc.