Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives
Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives
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口服避孕药改变血小板对花生四烯酸代谢物的反应
DOI：
10.1111/j.1365-2141.1984.tb06090.x
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发表时间：
1984
影响因子：
6.5
通讯作者：
K. Wu
中科院分区：
文献类型：
--
作者：
Jia;E. Hall;K. Wu
研究口服避孕药对血小板对花生四烯酸代谢物反应性的影响。将服用口服避孕药至少3个月的妇女的血小板与年龄匹配的对照组进行比较。基础和前列环素（PGI2）刺激的血小板cAMP水平在OC使用者中明显低于非使用者。两组间PGD2刺激的cAMP水平无显著差异。此外，OCs可显著增强血小板对TXA2激动剂U46619的聚集性。我们的数据表明，使用OC可以特异性地增强血小板对TXA2的反应性，同时抑制血小板对PGI2的反应性。因此，它们的总体效果将是有利于血栓形成的正常血小板反应的破坏。
The effects of oral contraceptive (OC) usage on platelet responsiveness to arachidonic acid metabolites was investigated. Platelets obtained from women who had been taking oral contraceptives for at least 3 months were compared with those of age‐matched controls. Both the basal and prostacyclin (PGI2)‐stimulated platelet cAMP levels were significantly lower in OC users than in non‐users. There was no significant difference in the PGD2‐stimulated cAMP levels between the two groups. Furthermore, platelet aggregability to U46619, a TXA2 agonist, was greatly enhanced by OCs. Our data suggests that OC usage can specifically enhance platelet responsiveness to TXA2 while suppressing platelet responsiveness to PGI2. Thus their overall effect would be a disruption of normal platelet responses in favour of thrombus formation.
高浓度花生四烯酸抑制血小板聚集和释放的机制研究
影响因子：
20.3
作者：
Linder,BL;Goodman,DS
通讯作者：
Goodman,DS