Human papillomavirus types 16 and 18 DNA load in relation to coexistence of other types, particularly those in the same species.
Human papillomavirus types 16 and 18 DNA load in relation to coexistence of other types, particularly those in the same species.
复制标题
人乳头瘤病毒 16 型和 18 型 DNA 载量与其他类型（尤其是同一物种中的病毒）共存相关。
DOI：
10.1158/1055-9965.epi-09-0482
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Schiffman,Mark
中科院分区：
文献类型：
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作者：
Xi,LongFu;Edelstein,ZoeR;Meyers,Craig;Ho,Jesse;Cherne,StephenL;Schiffman,Mark
Background: Infection with multiple human papillomavirus (HPV) types is common. However, it is unknown whether viral DNA load is related to the coexistence of other types.Methods: Study subjects were 802 and 303 women who were positive for HPV16 and HPV18, respectively, at enrollment into the Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion Triage Study. HPV16 and HPV18 E7 copies per nanogram of cellular DNA in cervical swab samples were measured by real-time PCR in triplicate.Results: Concurrent coinfection was common in this population of women with minor cervical lesions; multiple HPV types were detected in 573 (71.4%) of 802 HPV16-positive women and 227 (74.9%) of 303 HPV18-positive women. The adjusted odds ratio associating coinfection with per 1 log unit increase in HPV16 DNA load was 0.78 (95% confidence interval, 0.68-0.89); it was 0.64 (95% confidence interval, 0.52-0.79) for a similar analysis of HPV18 DNA load. Women with, compared with without, coinfection of A9 species types possessed a significantly lower HPV16 DNA load (P< 0.001), whereas women with, compared with without, coinfection of A7 species types possessed a significantly lower HPV18 DNA load (P= 0.001). A trend of decrease in HPV16 DNA load with increasing number of the coexisting non-HPV16 A9 species types was statistically significant (Ptrend= 0.001).Conclusion: Coinfection with other types was associated with lower HPV16 and HPV18 DNA load. The extent of reduction was correlated to phylogenetic distance of the coexisting types to HPV16 and HPV18, respectively. (Cancer Epidemiol Biomarkers Prev 2009;18(9):2507–12)
