CHOLECYSTOKININ ELICITS SATIETY IN RATS WITH OPEN GASTRIC FISTULAS
CHOLECYSTOKININ ELICITS SATIETY IN RATS WITH OPEN GASTRIC FISTULAS
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DOI：
10.1038/245323a0
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发表时间：
1973-01-01
期刊：
影响因子：
64.8
通讯作者：
SMITH, GP
中科院分区：
文献类型：
--
作者：
GIBBS, J;YOUNG, RC;SMITH, GP
开始进食后 10 分钟内，老鼠会停止进食1，进行短暂的梳理，然后通常会睡觉。我们将这种行为序列定义为饱腹感：其生理基础未知。 Beaumont2 提出了第一个证据，证明肠道中食物的存在对于产生饱腹感信号很重要。 1949年，雅诺维茨和格罗斯曼3证实了巴甫洛夫的观察结果4，即食管被切开的狗，由于没有食物到达胃或肠，因此进食时间较长。
WITHIN 10 min of starting to eat, a rat stops eating1, grooms for a short period, then usually sleeps. We define this behavioural sequence as satiety: its physiological basis is unknown. Beaumont2presented the first evidence that the presence of food in the gut is important in generating satiety signals. In 1949, Janowitz and Grossman3confirmed Pavlov's observation4that oesophagostomized dogs, in which no food reached the stomach or intestines, ate prolonged meals.