BALAMUTHIA-MANDRILLARIS, NG, N-SP, AGENT OF AMEBIC MENINGOENCEPHALITIS IN HUMANS AND OTHER ANIMALS
BALAMUTHIA-MANDRILLARIS, NG, N-SP, AGENT OF AMEBIC MENINGOENCEPHALITIS IN HUMANS AND OTHER ANIMALS
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DOI：
10.1111/j.1550-7408.1993.tb04943.x
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发表时间：
1993-07-01
影响因子：
2.2
通讯作者：
MARTINEZ, AJ
中科院分区：
文献类型：
--
作者：
VISVESVARA, GS;SCHUSTER, FL;MARTINEZ, AJ
我们最近报道了从一只死于脑膜脑炎的狒狒脑中分离出一种细黏液阿米巴。基于光镜和电镜研究，动物致病性试验，免疫荧光模式，我们得出结论，我们的分离物从根本上不同于其他两个阿米巴（Leptomyxa和Gephyramoeba）包括在订单Leptomyxida。因此，我们创造了一个新的属。Balamuthia，以容纳我们的分离物，并将其描述为Balamuthia mandrillaris，以反映模式种的起源。简单地说，B。mandrillaris是一种致病性阿米巴，可引起人类和动物的阿米巴脑炎。它在其生命周期中具有营养和包囊阶段，是单核的，有一个大的泡状核和一个中央核仁。成熟的包囊有三层壁，由外部松散的外囊、内部的内囊和中间的中囊组成。与引起人类阿米巴脑炎的其他两种阿米巴原虫--阿米巴原虫和耐格里原虫不同，Balamuthia不会在接种了肠道细菌的琼脂平板上生长。然而，Balamuthia在各种哺乳动物细胞培养物上生长，并在鼻内或腹膜内接种后杀死小鼠。根据免疫荧光检测，全世界有35例人类阿米巴脑炎和3例其他动物阿米巴脑炎被确定为由布拉穆西亚引起。
We recently reported the isolation of a leptomyxid ameba from the brain of a mandrill baboon that died of meningoencephalitis. Based on light and electron microscopic studies, animal pathogenicity tests, and immunofluorescence patterns, we conclude that our isolate differs fundamentally from the other two amebas (Leptomyxa and Gephyramoeba) included in the Order Leptomyxida. We therefore created a new genus. Balamuthia, to accommodate our isolate and described it as Balamuthia mandrillaris to reflect the origin of the type species. Briefly, B. mandrillaris is a pathogenic ameba that causes amebic encephalitis in humans and animals. It has trophic and cyst stages in its life cycle, and is uninucleate with a large vesicular nucleus and a central nucleolus. Mature cysts have a tripartite wall consisting of an outer loose ectocyst, an inner endocyst and a middle mesocyst. Unlike Acanthamoeba and Naegleria, the other two amebas that cause amebic encephalitis in humans, Balamuthia will not grow on agar plates seeded with enteric bacteria. However, Balamuthia grows on a variety of mammalian cell cultures and kills mice following intranasal or intraperitoneal inoculation. Based on immunofluorescence testing, 35 cases of amebic encephalitis in humans and three in other animals have been identified worldwide as being caused by Bulamuthia.