Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function
Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function
复制标题
精神分裂症患者旁边缘系统灰质体积减少：与临床变量、症状和认知功能的相关性。
DOI：
10.1016/j.jpsychires.2015.04.008
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发表时间：
2015-06-01
影响因子：
4.8
通讯作者：
Wang, Fei
中科院分区：
文献类型：
--
作者：
Liao, Jinmin;Yan, Hao;Wang, Fei
背景：精神病与组成副边缘系统的区域功能障碍有关，如眶额皮质（OFC）、岛叶皮质（IC）、颞极（TP）、海马旁回（PHG）和扣带皮质（CC）。然而，在精神分裂症中，这些区域的结构改变的发现是不一致的，并且副边缘系统测量与症状学和认知功能之间的相关性尚未被调查。方法：对93例精神分裂症患者和99例健康对照者进行结构磁共振成像和临床认知评价。我们使用基于体素的形态测量法比较了两组患者的灰质体积（GMV），并评估了异常GMV与临床变量、症状学和认知功能之间的相关性。对认知能力的评估包括处理速度、语言流畅性和记忆力。结果：精神分裂症患者副边缘系统GMV显著降低，包括双侧OFC、IC和TP （p < 0.05， FWE校正）。双侧颞上回（STG） GMV下降。所有被试的双侧OFC、左IC、左TP和双侧STG的gmv与加工速度呈正相关，双侧OFC的gmv与记忆功能呈正相关。在我们的患者组中，GMV缺陷还与发病年龄更早、病程更长、住院次数更多和阳性症状更严重有关。结论：精神分裂症患者副边缘系统gmv明显降低，其异常与临床变量、症状及认知功能相关。这些结果表明，副边缘系统在精神分裂症的病理生理中起重要作用。(C) 2015 Elsevier Ltd.版权所有。
Background: Psychopathy is associated with dysfunction in regions that compose the paralimbic system, such as the orbitofrontal cortex (OFC), insular cortex (IC), temporal pole (TP), parahippocampal gyrus (PHG) and cingulate cortex (CC). However, findings of structural alterations in these regions are inconsistent in schizophrenia, and correlations between paralimbic system measures and symptomatology and cognitive function have not been investigated.Method: 93 patients with schizophrenia and 99 healthy controls received structural magnetic resonance imaging and clinical and cognitive assessment. We compared gray matter volume (GMV) between the two groups using voxel-based morphometry, and evaluated correlations between abnormal GMVs and clinical variables, symptomatology and cognitive function. The assessment of cognition included measures of processing speed, verbal fluency and memory.Results: Patients with schizophrenia demonstrated significant GMV decreases in the paralimbic system, including bilateral OFC, IC and TP (p < 0.05, FWE corrected). GMV decreases were also observed in bilateral superior temporal gyri (STG). The GMVs in bilateral OFC, left IC, left TP and bilateral STG were positively correlated with processing speed, and the GMVs in bilateral OFC were positively correlated with memory function in all participants. In our patient group, the GMV deficits were also associated with earlier age of onset, longer duration of illness, greater number of hospitalizations and more severe positive symptoms.Conclusions: GMVs in the paralimbic system were significantly reduced in schizophrenia, and these abnormalities were correlated with clinical variables, symptomatology and cognitive function. These results suggest the paralimbic system plays an important role in the pathophysiology of schizophrenia. (C) 2015 Elsevier Ltd. All rights reserved.