Morphological Evaluation of Meibomian Glands Using Noncontact Infrared Meibography
Morphological Evaluation of Meibomian Glands Using Noncontact Infrared Meibography
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DOI：
10.1016/j.jtos.2012.09.005
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发表时间：
2013-01-01
期刊：
影响因子：
6.4
通讯作者：
Shimazaki, Jun
中科院分区：
文献类型：
--
作者：
Ban, Yumiko;Shimazaki-Den, Seika;Shimazaki, Jun
Meibography用于研究睑板腺（meibomian gland， MG）的形态学变化，半定量分析用于评估MG。本文采用非接触式红外meibography （NIM）技术对37名受试者进行了详细的MG形态计量学评估，并研究了MG形态与眼表的关系以及MG形态与年龄和性别的关系。上眼睑和下眼睑的微管在形态上表现出显著的相关性，前者的微管比后者长。MG导管的平均长度、MG腺泡面积百分比和腺体脱落数与年龄有显著相关。上、下眼睑MG管的平均长度分别与meibum （P= 0.043）和荧光素染色评分（P= 0.008）呈负相关。上睑MG腺泡百分率与泪膜破裂时间呈正相关（P= 0.012），与泪膜脂质层干涉测量法和减肥率呈负相关（P= 0.005和P= 0.005）。002年,分别)。男性下眼睑MG管的平均长度明显长于女性（P=.03）。这些结果表明，使用NIM进行形态计量分析可能有助于评估眼表状况。
Meibography is used to study morphological changes in the meibomian glands (MGs), and semi-quantitative analysis has been used for MG assessment. We conducted a detailed morphometric assessment of MGs using noncontact infrared meibography (NIM) and investigated the relationship between MG morphology and the ocular surface and MG morphology associated with aging and sex in 37 subjects. The MGs in the upper and lower eyelids showed significant correlations in their morphology, with the former having longer ducts than the latter. The mean length of the MG ducts, percent area of MG acini, and number of gland dropouts were significantly correlated with age. The mean length of the MG ducts in the upper and lower eyelids showed negative correlations with the meibum (P=.043) and fluorescein staining score (P=.008), respectively. The percent area of MG acini in the upper eyelid showed a positive correlation with tear film breakup time (P=.012) and negative correlations with tear film lipid layer interferometry and meibum (P=.005 and .002, respectively). The mean length of the male's MG ducts in the lower eyelid was significantly longer than that of the females (P=.03). These results indicate that morphometric analysis using NIM may be useful for assessing ocular surface conditions.