CAPTOPRIL IMPROVES IMPAIRED ENDOTHELIUM-DEPENDENT VASODILATION IN HYPERTENSIVE PATIENTS
CAPTOPRIL IMPROVES IMPAIRED ENDOTHELIUM-DEPENDENT VASODILATION IN HYPERTENSIVE PATIENTS
复制标题
DOI：
10.1161/01.hyp.20.2.175
复制
发表时间：
1992-08-01
期刊：
影响因子：
8.3
通讯作者：
TAKESHITA, A
中科院分区：
文献类型：
--
作者：
HIROOKA, Y;IMAIZUMI, T;TAKESHITA, A
动物研究表明，一些血管紧张素转换酶抑制剂增强内皮依赖性血管松弛。我们的目的是确定卡托普利是否能增强中年高血压患者内皮依赖性血管舒张。在卡托普利给药（25mg / s）前后，采用应变式容积描记法检测动脉内乙酰胆碱（4、8、16和24 μ g/min）或硝普苷（0.2、0.4、0.8和1.2 μ g/min）引起的前臂血管舒张。在卡托普利之前，高血压患者（n = 12）使用乙酰胆碱的前臂血管舒张作用小于年龄匹配（n = 7）或年轻（n = 7）血压正常者，但硝普塞的前臂血管舒张作用在三组之间没有差异。卡托普利改善高血压患者（n = 7）乙酰胆碱的前臂血管舒张，而硝普塞没有。相比之下，硝苯地平（10mg / s）没有改变高血压患者乙酰胆碱或硝普塞的前臂血管舒张（n = 5）。卡托普利和硝苯地平在高血压患者中引起的平均血压下降具有可比性。在血压正常的年轻受试者中，卡托普利没有改变乙酰胆碱或硝普赛的前臂血管舒张（n = 7）。这些结果表明，高血压患者卡托普利可以急性改善受损的内皮依赖性前臂血管舒张，而这种舒张不是由血压本身降低引起的。
Animal studies suggest that some angiotensin coverting enzyme inhibitors augment endothelium-dependent vasorelaxation. We aimed to determine if captopril augments endothelium-dependent vasodilation in middle-aged hypertensive patients. By using strain-gauge plethysmography, forearm vasodilation evoked with intra-arterial acetylcholine (4, 8, 16, and 24-mu-g/min) or nitroprusside (0.2, 0.4, 0.8, and 1.2 mu-g/min) was examined before and after captopril administration (25 mg per os). Before captopril, forearm vasodilation with acetylcholine was less in hypertensive patients (n = 12) than in age-matched (n = 7) or young (n = 7) normotensive subjects, but forearm vasodilation with nitroprusside did not differ among the three groups. Captopril improved forearm vasodilation in hypertensive patients (n = 7) with acetylcholine but nitroprusside did not. In contrast, nifedipine (10 mg per os) did not alter forearm vasodilation with acetylcholine or nitroprusside in hypertensive patients (n = 5). The decreases in mean blood pressure caused by captopril and nifedipine in hypertensive subjects were comparable. Captopril did not alter forearm vasodilation with acetylcholine or nitroprusside in young normotensive subjects (n = 7). These results suggest that captopril in hypertensive patients may acutely improve impaired endothelium-dependent forearm vasodilation that does not result from reduction in blood pressure per se.