ACTION OF CERTAIN ANTIBIOTICS ON MITOCHONDRIAL ERYTHROCYTE AND ARTIFICIAL PHOSPHOLIPID MEMBRANES - ROLE OF INDUCED PROTON PERMEABILITY
ACTION OF CERTAIN ANTIBIOTICS ON MITOCHONDRIAL ERYTHROCYTE AND ARTIFICIAL PHOSPHOLIPID MEMBRANES - ROLE OF INDUCED PROTON PERMEABILITY
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DOI：
10.1042/bj1110521
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发表时间：
1969-01-01
影响因子：
4.1
通讯作者：
CHAPPELL, JB
中科院分区：
文献类型：
--
作者：
HENDERSO.PJ;MCGIVAN, JD;CHAPPELL, JB
1. 研究了抗生素enniatin A、valinomycin、肌动蛋白同系物gramicidin、nigericinin和dianemycin对卵磷脂-磷酸二烷基氢的线粒体、红细胞和近聚中间期的作用。2. 这些抗生素诱导所有三种膜系统对碱金属阳离子的渗透性。3. 各膜系统的离子特异性相同。4. enenniatin A、valinomycin和actiins不能诱导质子渗透，而nigericin和dianemycin则使这三种膜系统对质子自由渗透。5. 尼日利亚菌素诱导的通透性与革兰菌素诱导的通透性存在差异。6. 如果假设呼吸线粒体中存在膜电位，所有这些抗生素对线粒体呼吸的作用可以通过线粒体膜被动离子通透性的变化来解释，类似于红细胞和磷脂膜中诱导的变化。
1. The action of the antibiotics enniatin A, valinomycin, the actin homologues, gramicidin, nigericin and dianemycin on mitochondria, erythrocytes and smectic mesophases of lecithin–dicetyl hydrogen phosphate was studied. 2. These antibiotics induced permeability to alkali-metal cations on all three membrane systems. 3. The ion specificity on each membrane system was the same. 4. Enniatin A, valinomycin and the actins did not induce permeability to protons, whereas nigericin and dianemycin rendered all three membrane systems freely permeable to protons. 5. Several differences were noted between permeability induced by nigericin and that induced by gramicidin. 6. The action of all these antibiotics on mitochondrial respiration could be accounted for by changes in passive ion permeability of the mitochondrial membrane similar to those induced in erythrocytes and phospholipid membranes, if it is assumed that a membrane potential is present in respiring mitochondria.