A quantitative model for differential motility of gliomas in grey and white matter
A quantitative model for differential motility of gliomas in grey and white matter
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DOI：
10.1046/j.1365-2184.2000.00177.x
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发表时间：
2000-10-01
影响因子：
8.5
通讯作者：
Murray, JD
中科院分区：
文献类型：
--
作者：
Swanson, KR;Alvord, EC;Murray, JD
与灰质相比，我们基于增殖和扩散速率扩展了胶质瘤的数学模型，以纳入白质细胞运动的影响。使用为MRI模拟器开发的大脑中的白色和灰质的详细映射，我们能够在解剖上精确的脑结构域上模拟模型肿瘤。我们的模拟与临床观察到的肿瘤几何形状显示出良好的一致性，并暗示了在CT或MRI图像上无法检测到的亚显微肿瘤侵袭的路径。我们希望该模型能够深入了解神经胶质瘤细胞对人脑的显微镜和亚显微镜侵袭。这种方法可以洞悉神经胶质瘤细胞对人脑的微观和亚显微镜侵袭。此外，该模型可用于定义神经胶质瘤细胞侵袭的预期途径，从而确定要聚焦治疗的大脑区域。
We have extended a mathematical model of gliomas based on proliferation and diffusion rates to incorporate the effects of augmented cell motility in white matter as compared to grey matter. Using a detailed mapping of the white and grey matter in the brain developed for a MRI simulator, we have been able to simulate model tumours on an anatomically accurate brain domain. Our simulations show good agreement with clinically observed tumour geometries and suggest paths of submicroscopic tumour invasion not detectable on CT or MRI images. We expect this model to give insight into microscopic and submicroscopic invasion of the human brain by glioma cells. This method gives insight in microscopic and submicroscopic invasion of the human brain by glioma cells. Additionally, the model can be useful in defining expected pathways of invasion by glioma cells and thereby identify regions of the brain on which to focus treatments.