Inflammatory response and body composition in chronic obstructive pulmonary disease
Inflammatory response and body composition in chronic obstructive pulmonary disease
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DOI：
10.1164/ajrccm.164.8.2008109
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发表时间：
2001-10-15
影响因子：
24.7
通讯作者：
Shale, DJ
中科院分区：
文献类型：
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作者：
Eid, AA;Ionescu, AA;Shale, DJ
慢性阻塞性呼吸道疾病(COPD)的体重减轻与呼吸能量成本的增加有关。为了确定身体成分和炎症反应之间的联系，我们研究了80名临床稳定的患者。用人体测量法测定身体成分，用肌酐身高指数(CHI)测定骨骼肌重。对40例患者进行了氮平衡测定。测定68例患者外周血中白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)及其可溶性受体的浓度。55例患者的体重指数(BMI)正常(>；20 kg/m(2))，其中17例(31%)有低CHI(<；80%预测)。CHI的降低与循环中IL-6(p=0.001)、肿瘤坏死因子-α(p=0.032)及其可溶性受体IL-6sr(p=0.002)、肿瘤坏死因子-αsr1(p=0.03)和肿瘤坏死因子-αsr2(p=0.001)水平的升高有关。正常的患者。BMI和低CHI患者的炎症介质水平与BMI和CHI低的患者相似；两者都显著高于BMI和CHI正常的患者。正常组和低CHI组之间的氮平衡相似，但低CHI组的氮排泄显著增加。脐带骨骼肌减少可能是多因素引起的，但我们的数据表明，即使体重减轻不明显，也与全身炎症有关。
Weight loss in chronic obstructive airways disease (COPD) is associated with an increased energy cost of breathing. To determine an association between body composition and the inflammatory response we studied 80 clinically stable patients. Body composition was determined anthropometrically and skeletal muscle mass was determined as the creatinine-height index (CHI). Forty patients had their nitrogen balance determined. Circulating concentrations of interieukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and their soluble receptors were determined for 68 patients. Body mass index (BMI) was normal (> 20 kg/m(2)) in 55 patients, of whom 17 (31%) had a low CHI (< 80% predicted). A reduced CHI was associated with increased circulating levels of IL-6 (p = 0.001), TNF-alpha (p = 0.032) and their soluble receptors IL-6sr (p = 0.002), TNF-alpha sr1 (p = 0.03), and TNF-alpha sr2 (p = 0.001). Patients with a normal. BMI and low CHI had inflammatory mediator levels similar to patients with a low BMI and CHI; both were significantly greater than in those with a normal BMI and CHI. Nitrogen balance was similar between normal and low CHI groups, although nitrogen excretion was significantly increased in the low CHI group. Skeletal muscle loss in CORD is probably multifactorial in origin, but our data suggest a link with systemic inflammation, even when weight loss is inapparent.