RADIOTHERAPY FOR SYMPTOMATIC VERTEBRAL HEMANGIOMAS: RESULTS OF A MULTICENTER STUDY AND LITERATURE REVIEW
RADIOTHERAPY FOR SYMPTOMATIC VERTEBRAL HEMANGIOMAS: RESULTS OF A MULTICENTER STUDY AND LITERATURE REVIEW
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DOI：
10.1016/j.ijrobp.2009.04.055
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发表时间：
2010-05-01
影响因子：
7
通讯作者：
Micke, Oliver
中科院分区：
文献类型：
--
作者：
Heyd, Reinhard;Seegenschmedt, M. Heinrich;Micke, Oliver
目的：目前的研究分析了放射治疗（RT）在症状性脊椎血管瘤（SVH）的潜在作用。方法和材料：七个合作的德国机构收集的临床信息，治疗计划，和结果数据的所有患者与SVH提到的本地RT.Results：从1969年至2008年，共84例患者96症状性病变进行了照射SVH。放疗的主要适应症是疼痛（97.6%），28.6%的患者有其他神经系统症状。RT的中位总剂量为34戈伊，中位单次剂量为2.0戈伊。在接受中位随访68个月后，患者的总体反应率为90.5%。61.9%的患者症状完全缓解，28.6%的患者疼痛部分缓解，9.5%的患者疼痛无缓解。在26.2%的患者中，在长期随访中观察到再骨化的放射学体征，但与疼痛缓解无显著相关性。最重要的是，>= 34戈伊的总剂量导致的症状缓解和控制率显著高于
Purpose: The current study analyzes the potential role of radiotherapy (RT) in symptomatic vertebral hemangioma (SVH).Methods and Materials: Seven cooperating German institutions collected clinical information, treatment plans, and outcome data for all patients with SVH referred for local RT.Results: From 1969 to 2008, a total of 84 patients with 96 symptomatic lesions were irradiated for SVH. The primary indication for radiotherapy was pain (97.6%), and 28.6% of patients had additional neurological symptoms. RT was performed at a median total dose of 34 Gy, with a median single dose of 2.0 Gy. After receiving a median follow-up of 68 months, the overall patient response rate was 90.5%. Complete symptom remission occurred in 61.9% of patients, 28.6% of patients had partial pain relief, and 9.5% of patients had no pain relief. In 26.2% of patients, radiological signs of reossification were observed in long-term follow-up but not significantly correlated with pain relief. Most importantly, total doses of >= 34 Gy resulted in significantly greater symptomatic relief and control rate than total doses of