THE SURGICAL-TREATMENT OF ATRIAL-FIBRILLATION .3. DEVELOPMENT OF A DEFINITIVE SURGICAL-PROCEDURE
THE SURGICAL-TREATMENT OF ATRIAL-FIBRILLATION .3. DEVELOPMENT OF A DEFINITIVE SURGICAL-PROCEDURE
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DOI：
10.1016/s0022-5223(19)36684-x
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发表时间：
1991-04-01
影响因子：
6
通讯作者：
BOINEAU, JP
中科院分区：
文献类型：
--
作者：
COX, JL;SCHUESSLER, RB;BOINEAU, JP
基于已知的心房颤动的电生理机制，设计了多种外科手术并在犬中进行了测试，以确定开发人类心房颤动外科治疗的可行性。 这些实验研究最终导致了一种外科方法，该方法有效地在心房中创建了一个电迷宫。 心房切口可防止心房折返，并允许窦性冲动激活整个心房心肌，从而在术后保留心房转运功能。 自1987年9月以来，该手术已应用于7例患者，其中5例阵发性房颤持续时间为2至9年，2例慢性房颤持续时间为3年和10年。 所有7名患者的房颤都已治愈，没有人正在接受任何术后抗心律失常药物治疗。
On the basis of the known electrophysiologic mechanisms of atrial fibrillation, multiple surgical procedures were designed and tested in dogs to determine the feasibility of developing a surgical cure for human atrial fibrillation. These experimental studies culminated in a surgical approach that effectively creates an electrical maze in the atrium. The atrial incisions prevent atrial reentry and allow sinus impulses to activate the entire atrial myocardium, thereby preserving atrial transport function postoperatively. Since September 1987, this surgical procedure has been applied in seven patients, five with paroxysmal atrial fibrillation of 2 to 9 years' duration and two with chronic atrial fibrillation of 3 and 10 years' duration. All seven patients have been cured of atrial fibrillation and none is receiving any postoperative antiarrhythmic medications.