CUTANEOUS HYPERALGESIA INDUCED BY PERIPHERAL INJECTION OF INTERLEUKIN-1-BETA IN THE RAT
CUTANEOUS HYPERALGESIA INDUCED BY PERIPHERAL INJECTION OF INTERLEUKIN-1-BETA IN THE RAT
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DOI：
10.1016/0006-8993(94)90960-1
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发表时间：
1994-09-19
期刊：
影响因子：
2.9
通讯作者：
TAKESHIGE, C
中科院分区：
文献类型：
--
作者：
FUKUOKA, H;KAWATANI, M;TAKESHIGE, C
通过记录大鼠背根对机械刺激和热刺激的动作电位，研究了足底注射白细胞介素1β(IL-1β)后，传入纤维在痛觉和痛敏中的作用。触摸刺激是通过用棉头涂抹器抚摸来传递的，热刺激是通过冷却或加热皮肤来施加的。在给予IL-1β(100pg-1 mg)后，对触摸、冷和热刺激的反应分别增加到对照组的143%、200%和392%。在50%的实验中，IL-1β诱导的短暂性自发放电。IL-1β在1min内作用明显。为了检测对压力刺激的反应，用机械刺激器按压了1 mm(2)的后爪皮肤。IL-1β(0.1pg-200 ng)将阈值降低到发射所需控制压力的58%。IL-1β也增加了对不同压力水平(范围：1-20g/mm(2))的反应。这些数据表明，IL-1β可能通过激活机械刺激和热刺激的多通道受体在皮肤痛敏中发挥重要作用。
The contribution of the activity of afferent fiber filaments to pain and hyperalgesia after administration of a plantar injection of interleukin-1 beta (IL-1 beta) to the hind-paw skin was investigated by recording action potentials of the rat dorsal root in response to mechanical and thermal stimuli. Touch stimuli were delivered by stroking with a cotton-tipped applicator and thermal stimulation was applied by cooling or heating of the skin. After the administration of IL-1 beta (100 pg-1 mu g), responses to touch, cold, and heat stimulation increased to 143%, 200%, and 392%, respectively, of control values on average. IL-1 beta induced transient spontaneous discharge in 50% of experiments. The effects of IL-1 beta were apparent within 1 min. To examine responses to pressure stimulation, an area of 1 mm(2) of the hind-paw skin was pressed by a mechanical stimulator. IL-1 beta (0.1 pg-200 ng) decreased the threshold value to 58% of the control pressure required for firing. IL-1 beta also increased responses to various levels of pressure (range: 1-20 g/mm(2)). These data suggest that IL-1 beta may play an important role in cutaneous hyperalgesia by activating polymodal receptors to mechanical and thermal stimulation.