Data on the effect of in utero exposure to polycyclic aromatic hydrocarbons on genome-wide patterns of DNA methylation in lung tissues.
Data on the effect of in utero exposure to polycyclic aromatic hydrocarbons on genome-wide patterns of DNA methylation in lung tissues.
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DOI：
10.1016/j.dib.2017.06.023
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发表时间：
2017-08
期刊：
影响因子：
1.2
通讯作者：
Benninghoff AD
中科院分区：
文献类型：
--
作者：
Fish TJ;Benninghoff AD
本文中的数据描述了与未暴露后代相比，从子宫内暴露于苯并[a]芘（BaP）或二苯并[def，p]芘（DBC）的B6129 SF 1/J母畜和129 S1/SvImJ公畜的后代中获得的肺组织甲基化模式。使用甲基化DNA免疫沉淀（MeDIP）和NimbleGen小鼠DNA甲基化CpG岛阵列测定成年后代肺肿瘤的全基因组甲基化。本资料文章参考了研究文章《宫内暴露于多环芳烃的小鼠后代肺组织中的DNA甲基化》，其中提供了全面的数据解读和分析。
Data in this article depict patterns of methylation in lung tissues obtained from the offspring of B6129SF1/J dams and 129S1/SvImJ sires exposed in utero to benzo[a]pyrene (BaP) or dibenzo[def,p]chrysene (DBC) as compared to non-exposed offspring. Genome-wide methylation of lung tumors in adult offspring was determined using methylated DNA immunoprecipitation (MeDIP) with the NimbleGen mouse DNA methylation CpG island array. This data article refers to the research article “DNA methylation in lung tissues of mouse offspring exposed in utero to polycyclic aromatic hydrocarbons,” in which comprehensive data interpretation and analysis are provided.