Prevalence of sarcopenia in older patients with colorectal cancer
Prevalence of sarcopenia in older patients with colorectal cancer
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DOI：
10.1016/j.jgo.2015.08.005
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发表时间：
2015-11-01
影响因子：
3
通讯作者：
Muss, Hyman B.
中科院分区：
文献类型：
--
作者：
Broughman, James R.;Williams, Grant R.;Muss, Hyman B.
目的：肌肉减少症是与年龄相关的肌肉质量、力量和功能的丧失。这是老年患者的常见发现，与预期寿命缩短和对化疗毒性的潜在易感性增加有关。本研究描述了肌肉减少症在老年人早期结直肠癌的患病率。材料和方法：从2008年至2013年期间接受手术切除的270岁结直肠癌患者的病历中确定。通过测量手术前获得的计算机断层扫描（CT）图像上的总肌肉面积来评估肌肉减少症。在L3水平测量总肌肉面积，并使用每个患者的身高进行标准化，以产生骨骼肌指数（SMI）。使用性别和体重指数（BMI）的特定阈值SMI.Results：87例患者被定义为肌肉减少症，中位年龄为77岁（70-96）。25名男性（42人中的60%）和25名女性（45人中的56%）患有肌肉减少症。与非肌肉减少症患者相比，肌肉减少症患者的BMI显著降低（p = 0.03）。BMI与SMI在男性（r = 0.44）和女性（r = 0.16）中均呈正相关。单独的BMI是瘦体重的不良指标，需要改进筛选肌肉减少症的方法。CT扫描是识别肌肉减少症患者的可行选择，及时干预可以改善生存率，生活质量和功能结局。(C)2015爱思唯尔有限公司版权所有。
Objective: Sarcopenia is the age-related loss of muscle mass, strength, and function. It is a common finding in older patients and is associated with decreased life expectancy and potentially higher susceptibility to chemotherapy toxicity. This study describes the prevalence of sarcopenia in older adults with early stage colorectal cancer.Materials and Methods: Patients 270 years old who underwent surgical resection for stage colorectal cancer between 2008 and 2013 were identified from the medical record. Sarcopenia was assessed by measuring the total muscle area on computerized tomography (CT) images obtained prior to surgery. Total muscle area was measured at the level of L3 and normalized using each patient's height to produce a skeletal muscle index (SMI). Sarcopenia was defined using sex- and body mass index (BMI)-specific threshold values of SMI.Results: Eighty-seven patients were included, with a median age of 77 years (70-96). Twenty-five men (60% of 42) and 25 women (56% of 45) had sarcopenia. Sarcopenic patients had significantly lower BMI (p = 0.03) compared to non-sarcopenic patients. There was a positive correlation between BMI and SMI for both men (r = 0.44) and women (r = 0.16).Conclusion: Sarcopenia is highly prevalent among older patients with early stage colorectal cancer. BMI alone is a poor indicator of lean body mass and improved methods of screening for sarcopenia are necessary. CT scans are a viable option for identifying sarcopenic patients in whom timely interventions may improve survival, quality of life, and functional outcomes. (C) 2015 Elsevier Ltd. All rights reserved.