Morphine restores and naloxone-precipitated withdrawal depresses wheel running in rats with hindpaw inflammation.
Morphine restores and naloxone-precipitated withdrawal depresses wheel running in rats with hindpaw inflammation.
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DOI：
10.1016/j.pbb.2021.173251
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Ataras K
中科院分区：
文献类型：
--
作者：
Morgan MM;Ataras K
吗啡等阿片类药物是最有效的疼痛治疗方法，但终止阿片类药物的使用会产生严重的戒断症状。本研究通过使用家庭笼轮运行来评估疼痛，吗啡镇痛和阿片类药物戒断导致的幸福感，从而模拟了这一过程。将CFA注射到右后爪中引起轮跑和体重的急剧下降。植入两个吗啡丸（各75 mg）导致给药第1天体重增加，并且仅在吗啡给药第3天和第4天昼夜节律周期的黑暗期明显恢复轮运行。连续吗啡给药减少车轮运行在相对不活跃的光相。这些发现与疼痛治疗的临床目标一致，即在白天恢复正常活动并促进夜间睡眠。在吗啡给药第5天给予纳洛酮（1 mg/kg）可抑制转轮运行约4小时，并导致湿狗抖动增加。给药后6小时，纳洛酮沉淀的变化不再明显。这些发现表明，使用吗啡治疗疼痛并不能防止阿片类药物戒断。此外，这项研究提供了额外的支持，使用家庭笼轮运行作为一种方法，以评估由于疼痛，镇痛和阿片类药物戒断而导致的健康变化。
Opioids such as morphine are the most effective treatment for pain, but termination of opioid use can produce severe withdrawal symptoms. The present study models this process by using home cage wheel running to assess well-being as a result of pain, morphine analgesia, and opioid withdrawal. Injection of CFA into the right hindpaw caused a dramatic decrease in wheel running and body weight. Implantation of two morphine pellets (75 mg each) resulted in an increase in body weight on Day 1 of administration and a more gradual restoration of wheel running that was only evident during the dark phase of the circadian cycle on Days 3 and 4 of morphine administration. Continuous morphine administration decreased wheel running during the relatively inactive light phase. These findings are consistent with the clinical goal of pain therapeutics to restore normal activity during the day and facilitate sleep at night. Administration of naloxone (1 mg/kg) on Day 5 of morphine administration depressed wheel running for approximately 4 hrs and caused an increase in wet dog shakes. Naloxone-precipitated changes were no longer evident 6 hrs after administration. These findings demonstrate that the use of morphine to treat pain does not protect against opioid withdrawal. Moreover, this study provides additional support for the use of home cage wheel running as a method to assess changes in well-being as a result of pain, analgesia, and opioid withdrawal.
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炎症引起的大鼠炎症引起的家用笼子抑制的分析揭示了阿片类药物抗伤害感和功能恢复之间的差异。
影响因子：
2.7
作者：
Kandasamy, Ram;Calsbeek, Jonas J.;Morgan, Michael M.
通讯作者：
Morgan, Michael M.
影响因子：
3.6
作者：
Kandasamy, Ram;Lee, Andrea T.;Morgan, Michael M.
通讯作者：
Morgan, Michael M.
影响因子：
2.5
作者：
LERIDA, M;SANCHEZBLAZQUEZ, P;GARZON, J
通讯作者：
GARZON, J
影响因子：
5
作者：
GOLD, LH;STINUS, L;KOOB, GF
通讯作者：
KOOB, GF
使用式家用笼子跑步来评估施用MU/Delta阿片受体异二聚体拮抗剂的行为效应，以便大鼠自发性吗啡戒断。
影响因子：
2.7
作者：
Morgan MM;Peecher DL;Streicher JM
通讯作者：
Streicher JM