miRNAs in acute myeloid leukemia.
miRNAs in acute myeloid leukemia.
复制标题
急性髓系白血病中的 miRNA
DOI：
10.18632/oncotarget.12343
复制
发表时间：
2017-01-10
期刊：
影响因子：
--
通讯作者：
Jiang G
中科院分区：
文献类型：
--
作者：
Liao Q;Wang B;Li X;Jiang G
MicroRNAs(MiRNAs)是广泛存在于真核生物中的非编码小RNA，它控制着一些基因的表达，这些基因与造血干细胞的承诺和分化以及肿瘤的发生有关。在包括人类急性髓系白血病(AML)在内的血液系统恶性肿瘤中发现了广泛的miRNAs调节失调。全面了解miRNAs在恶性AML细胞中被破坏的复杂调控网络中的作用是开发使用miRNA调节剂的治疗策略的先决条件。在这里，我们回顾了新兴的miRNAs和miRNAs调控网络在AML发病机制、预后和miRNA指导的治疗中的作用。
MicroRNAs (miRNAs) are small, non-coding RNAs found throughout the eukaryotes that control the expression of a number of genes involved in commitment and differentiation of hematopoietic stem cells and tumorigenesis. Widespread dysregulation of miRNAs have been found in hematological malignancies, including human acute myeloid leukemia (AML). A comprehensive understanding of the role of miRNAs within the complex regulatory networks that are disrupted in malignant AML cells is a prerequisite for the development of therapeutic strategies employing miRNA modulators. Herein, we review the roles of emerging miRNAs and the miRNAs regulatory networks in AML pathogenesis, prognosis, and miRNA-directed therapies.