Toxoplasma gondii impairs memory in infected seniors
Toxoplasma gondii impairs memory in infected seniors
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DOI：
10.1016/j.bbi.2013.11.019
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发表时间：
2014-02-01
影响因子：
15.1
通讯作者：
Golka, Klaus
中科院分区：
文献类型：
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作者：
Gajewski, Patrick D.;Falkenstein, Michael;Golka, Klaus
近30%的人呈弓形虫抗体阳性，其流行率随年龄增长而增加。中枢神经系统是主要目标。然而，关于无症状即潜伏性弓形虫病对人类认知功能的影响知之甚少。为了研究无症状老年人弓形虫抗体阳性的神经认知功能障碍，进行了双盲神经心理学研究。参与者从基于人群的样本（N = 131） 65岁及以上的健康参与者中分为两组，每组42人：弓形虫病阳性（T-pos; IgG bb0 50 IU/ml）和弓形虫病阴性（t -阴性；IgG = 0 IU/ml）。结果测量是基于计算机的工作记忆测试（2-back）和一些标准化的记忆和执行认知功能的心理测试。T-pos老年人表现出不同方面的记忆损伤。在2-back任务中，正确识别目标符号的比率下降了近9% (P = 0.020)，相对于t -阴性组，工作记忆的表现下降了约35%。此外，T-pos高年级学生在言语记忆测试中的表现较差，无论是在即时记忆方面（下降10%，P = 0.022），延迟识别方面（下降6%，P = 0.037），还是在单词流畅性测试评估的长期记忆方面（下降12%，P = 0.029）。相比之下，执行功能没有受到影响。在控制服药后，效果基本保持不变。T-pos老年人的记忆功能受损伴随着自我报告的生活质量下降。由于无症状弓形虫病的高流行率和老年人人口的增加，这一发现与公共卫生高度相关。(C) 2013爱思唯尔公司版权所有。
Almost 30% of humans present a Toxoplasma gondii positive antibody status and its prevalence increases with age. The central nervous system is the main target. However, little is known about the influence of asymptomatic i.e. latent Toxoplasmosis on cognitive functions in humans. To investigate neurocognitive dysfunctions in asymptomatic older adults with T. gondii positive antibody status a double-blinded neuropsychological study was conducted. The participants were classified from a population-based sample (N = 131) of healthy participants with an age of 65 years and older into two groups with 42 individuals each: Toxoplasmosis positive (T-pos; IgG > 50 IU/ml) and Toxoplasmosis negative (T-neg; IgG = 0 IU/ml). The outcome measures were a computer-based working-memory test (2-back) and several standardized psychometric tests of memory and executive cognitive functions. T-pos seniors showed an impairment of different aspects of memory. The rate of correctly detected target symbols in a 2-back task was decreased by nearly 9% (P = 0.020), corresponding to a performance reduction of about 35% in working memory relative to the T-neg group. Moreover, T-pos seniors had a lower performance in a verbal memory test, both regarding immediate recall (10% reduction; P = 0.022), delayed recognition (6%; P = 0.037) and recall from long-term memory assessed by the word fluency tests (12%; P = 0.029). In contrast, executive functions were not affected. The effects remained mostly unchanged after controlling for medication. The impairment of memory functions in T-pos seniors was accompanied by a decreased self-reported quality of life. Because of the high prevalence of asymptomatic Toxoplasmosis and an increasing population of older adults this finding is of high relevance for public health. (C) 2013 Elsevier Inc. All rights reserved.