Myocardial deformation recovery from cine MRI using a nearly incompressible biventricular model
Myocardial deformation recovery from cine MRI using a nearly incompressible biventricular model
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DOI：
10.1016/j.media.2007.10.009
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发表时间：
2008-02-01
影响因子：
10.9
通讯作者：
Skrinjar, Oskar
中科院分区：
文献类型：
--
作者：
Bistoquet, Arnaud;Oshinski, John;Skrinjar, Oskar
本文提出了一种从电影MRI中恢复双心室心肌形变的方法。该方法基于几乎不可压缩的可变形模型，这是一种理想的属性，因为心肌已被证明是几乎不可压缩的。该模型使用矩阵值径向基函数来表示无发散位移场，这是不可压缩性的一阶近似。该表示允许具有相对少量的参数的任意拓扑的变形建模，其适合于表示心脏的多腔室结构的运动。该方法首先在初始帧中对心肌进行分割，然后自动确定整个心动周期中心肌各处的组织形变。在第一项研究中，从健康志愿者的3D解剖电影MRI序列中恢复心肌变形，然后根据双心室壁的手动分割和相应的3D标记电影MRI序列进行验证。模型与人工分割的平均体积一致率为3.2%，假阴性率为2.8%，真阳性率为91.4%。模型与手动确定的垂直标记平面的交点之间的平均距离为1.7 mm（1.2像素）。在四个月后对同一志愿者进行的另一组3D解剖和标记MRI扫描上重复相同的程序。恢复的变形与从第一组扫描获得的变形非常相似。在第二项研究中，该方法被应用到三维解剖电影MRI扫描的三名患者与心室不同步和三个年龄匹配的健康志愿者。正常受试者的恢复菌株明显强于患者的恢复菌株，并且与其他研究人员报告的菌株相似。根据双心室壁的手动分割和相应的标记MRI扫描，对所有6名受试者的恢复变形进行了验证。该协议类似于第一项研究。(C)2007 Elsevier B.V.保留所有权利。
This paper presents a method for biventricular myocardial deformation recovery from cine MRI. The method is based on a deformable model that is nearly incompressible, a desirable property since the myocardium has been shown to be nearly incompressible. The model uses a matrix-valued radial basis function to represent divergence-free displacement fields, which is a first order approximation of incompressibility. This representation allows for deformation modeling of an arbitrary topologies with a relatively small number of parameters, which is suitable for representing the motion of the multi-chamber structure of the heart. The myocardium needs to be segmented in an initial frame after which the method automatically determines the tissue deformation everywhere in the myocardium throughout the cardiac cycle.Two studies were carried out to validate the method. In the first study the myocardial deformation was recovered from a 3D anatomical cine MRI sequence of a healthy volunteer and then validated against the manual segmentation of the biventricular wall and against the corresponding 3D tagged cine MRI sequence. The average volume agreement between the model and the manual segmentation had a false positive rate of 3.2%, false negative rate of 2.8% and true positive rate of 91.4%. The average distance between the model and manually determined intersections of perpendicular tag planes was 1.7 mm (1.2 pixel). The same procedures was repeated on another set of 3D anatomical and tagged MRI scans of the same volunteer taken four months later. The recovered deformation was very similar to the one obtained from the first set of scans. In the second study the method was applied to 3D anatomical cine MRI scans of three patients with ventricular dyssynchrony and three age-matched healthy volunteers. The recovered strains of the normal subjects were clearly stronger than the recovered strains of the patients and they were similar to those reported by other researchers. The recovered deformation of all six subjects was validated against manual segmentation of the biventricular wall and against corresponding tagged MRI scans. The agreement was similar to that of the first study. (C) 2007 Elsevier B.V. All rights reserved.