Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk alopecia
Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk alopecia
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DOI：
10.1111/j.1432-0436.2004.07208006.x
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发表时间：
2004-10-01
期刊：
影响因子：
2.9
通讯作者：
Christiano, AM
中科院分区：
文献类型：
--
作者：
Uyttendaele, H;Panteleyev, AA;Christiano, AM
Notch信号通路已被证明在小鼠发育过程中控制细胞命运决定。为了研究Notch1在小鼠毛囊内表皮分化和各种细胞类型发育中的作用，我们在天花素启动子的控制下，培养了表达Notch1组成型激活形式的转基因小鼠。转基因动物在基底上表皮角质形成细胞和毛囊内根鞘中表达转基因基因，并产生皮肤和毛发异常。Notch1过表达导致表皮分化细胞区增多，延缓内根鞘分化，导致毛干异常和与毛发周期生长期相关的脱发。
The Notch signaling pathway has been shown to control cell-fate decisions during mouse development. To study the role of Notch1 in epidermal differentiation and the development of the various cell types within the mouse hair follicle, we generated transgenic mice that express a constitutive activated form of Notch1 under the control of the involucrin promoter. Transgenic animals express the transgene in the suprabasal epidermal keratinocytes and inner root sheath of the hair follicle, and develop both skin and hair abnormalities. Notch1 overexpression leads to an increase of the differentiated cell compartment in the epidermis, delays inner root sheath differentiation, and leads to hair shaft abnormalities and alopecia associated with the anagen phase of the hair cycle.