[The analysis of prescription frequency and the factors on adverse reactions of NSAIDs for post-operative pain in orthopedic patients].
[The analysis of prescription frequency and the factors on adverse reactions of NSAIDs for post-operative pain in orthopedic patients].
复制标题
非甾体类抗炎药治疗骨科患者术后疼痛的用药频率及不良反应影响因素分析
DOI：
10.1248/yakushi.123.613
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
M. Hirano
中科院分区：
文献类型：
--
作者：
Y. Ise;Y. Murota;K. Takayama;M. Narita;Tsutomu Suzuki;S. Soh;Shirou Katayama;M. Hirano
近年来，非甾体类抗炎药（NSAIDs）的不良反应问题日益突出，尽管非甾体类抗炎药是世界范围内最常用的药物之一。因此，对我院骨科术后疼痛患者使用非甾体抗炎药的处方频次及不良反应影响因素进行调查具有一定的研究价值。在骨科领域，各类非甾体抗炎药中以洛索洛芬处方最多。Logistic回归分析强烈提示既往药物（非NSAIDs）或食物引起的不良反应或过敏是NSAIDs不良反应的重要因素。此外，胃肠道溃疡既往病史与非甾体抗炎药胃肠道并发症之间存在显著相关性。此外，本研究指出药师对非甾体抗炎药不良反应的临床干预可以节省医疗费用。虽然还需要进一步的研究，但这些研究为骨科患者术后疼痛的药物管理和指导任务（即住院患者的药物护理和咨询）提供了良好的信息。
Recently, adverse reaction of non-steroidal anti-inflammatory drugs (NSAIDs) is the critical problem, although NSAIDs are one of the most commonly used classes of medications worldwide. Therefore, it is worthwhile to investigate the prescription frequency and the factors on adverse reactions of NSAIDs for post-operative pain in orthopedic patients of our hospital. In orthopedic field, loxoprofen was most prescribed in various kinds of NSAIDs. Logistic regression analysis strongly indicated that previous adverse reaction or allergy caused by drugs (not NSAIDs) or food is the important role in the adverse reaction of NSAIDs. In addition, significant correlation was observed between previous illness of gastrointestinal ulcer and gastrointestinal complication of NSAIDs. Moreover, the present study point out that pharmacist clinical intervention against the adverse reaction of NSAIDs may be saved on medical costs. Although further investigation may be needed, these present studies provide the good information for our medication management and instruction tasks (i.e. pharmaceutical care and counseling for inpatients) for post-operative pain of orthopedic patients.