Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
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DOI：
10.1073/pnas.081071198
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发表时间：
2001-04-10
影响因子：
11.1
通讯作者：
Fienberg, AA
中科院分区：
文献类型：
--
作者：
Hakak, Y;Walker, JR;Fienberg, AA
神经病理学和脑成像研究表明，精神分裂症可能是由于神经发育缺陷。细胞结构研究表明，精神分裂症患者的细胞异常提示神经元连接中断，特别是在背外侧前额叶皮层。然而，这些发现背后的分子机制仍不清楚。为了确定与精神分裂症相关的分子底物，DNA微阵列分析被用来检测精神分裂症患者和对照患者死后背外侧前额叶皮层的基因表达水平。确定在精神分裂症患者中相对于对照具有改变的表达水平的基因参与许多生物过程，包括突触可塑性、神经元发育、神经传递和信号转导。最值得注意的是髓鞘形成相关基因的差异表达，表明精神分裂症患者少突胶质细胞功能受到破坏。
Neuropathological and brain imaging studies suggest that schizophrenia may result from neurodevelopmental defects. Cytoarchitectural studies indicate cellular abnormalities suggestive of a disruption in neuronal connectivity in schizophrenia, particularly in the dorsolateral prefrontal cortex. Yet, the molecular mechanisms underlying these findings remain unclear. To identify molecular substrates associated with schizophrenia, DNA microarray analysis was used to assay gene expression levels in postmortem dorsolateral prefrontal cortex of schizophrenic and control patients. Genes determined to have altered expression levels in schizophrenics relative to controls are involved in a number of biological processes, including synaptic plasticity, neuronal development, neurotransmission, and signal transduction. Most notable was the differential expression of myelination-related genes suggesting a disruption in oligodendrocyte function in schizophrenia.