IDENTIFICATION OF HUMAN ACTIVIN AND TGF-BETA TYPE-I RECEPTORS THAT FORM HETEROMERIC KINASE COMPLEXES WITH TYPE-II RECEPTORS
IDENTIFICATION OF HUMAN ACTIVIN AND TGF-BETA TYPE-I RECEPTORS THAT FORM HETEROMERIC KINASE COMPLEXES WITH TYPE-II RECEPTORS
复制标题
DOI：
10.1016/0092-8674(93)90488-c
复制
发表时间：
1993-11-19
期刊：
影响因子：
64.5
通讯作者：
WRANA, JL
中科院分区：
文献类型：
--
作者：
ATTISANO, L;CARCAMO, J;WRANA, JL
转化生长因子β（TGFBETA）和激活素各种结合与形成信号复合物的膜蛋白（称为I型受体I和II）对。我们报告说，TSR-I和ACTR-I是两个与TGFBETA和II型受体相关的人跨膜丝氨酸/苏氨酸激酶，充当I型受体的这些因素。 TSR-I是TGFBETA和AIVIVIN共有的I型受体，而ACTR-I是一种激活素I型受体。 ACTR-I（而不是TSR-I）与Activin II型受体一起表示特定的转录反应。结果表明，I型受体是跨膜蛋白激酶，它们与II型受体相关，以产生不同信号能力的多种异源丝氨酸/苏氨酸激酶复合物。
Transforming growth factor beta (TGFbeta) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases distantly related to TGFbeta and activin type II receptors, act as type I receptors for these factors. TSR-I is a type I receptor shared by TGFbeta and activin, whereas ActR-I is an activin type I receptor. ActR-I, but not TSR-I, signals a particular transcriptional response in concert with activin type II receptors. The results indicate that type I receptors are transmembrane protein kinases that associate with type II receptors to generate diverse heteromeric serine/threonine kinase complexes of different signaling capacities.