A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells
复制标题
DOI：
10.1016/j.febslet.2005.03.079
复制
发表时间：
2005-05-09
期刊：
影响因子：
3.5
通讯作者：
Takagaki, K
中科院分区：
文献类型：
--
作者：
Yoshihara, S;Kon, A;Takagaki, K
4-Methylumbelliferone (MU) inhibits the cell surface hyaluronan (HA) formation, and that such inhibition results in suppression of adhesion and locomotion of cultured melanoma cells. Here, we examine the effect of MU on melanoma cell metastasis in vivo. MU-treated melanoma cells showed both decreased cell surface HA formation and suppression of liver metastasis after injection into the mice. Oral administration of MU to mice decreased tissue HA content. These HA knockdown mice displayed suppressed liver metastasis. Thus, both cell surface HA of melanoma cells and recipient liver HA can promote liver metastasis, indicating that MU has potential as an anti-metastatic agent. (c) 2005 Federation of European. Biochemical Societies. Published by Elsevier B.V. All rights reserved.
