Human exposure to Bisphenol A and liver health status: Quantification of urinary and circulating levels by LC-MS/MS
Human exposure to Bisphenol A and liver health status: Quantification of urinary and circulating levels by LC-MS/MS
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DOI：
10.1016/j.jpba.2017.02.058
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发表时间：
2017-06-05
影响因子：
3.4
通讯作者：
Diano, Nadia
中科院分区：
文献类型：
--
作者：
Nicolucci, Carla;Erric, Sonia;Diano, Nadia
开发并验证了一种用于测定人血浆中双酚A的选择性和高灵敏度分析方法。该方法基于选择性液/固萃取，结合液相色谱-电喷雾串联质谱（LC-ESI-MS）的多反应监测模式和负离子源。在0.100-200 ng mL（-1）浓度范围内，在人血浆中验证了检测器响应的线性。检测限为0.03 ng mL（-1），定量限为0.100 ng mL（-1）。拟定的内部验证方法的分析特征令人满意：精密度为
A selective and highly sensitive analytical methodology for determination of Bisphenol A in human plasma was developed and validated. The method was based on selective liquid/solid extraction, combined with liquid chromatography-electrospray ionization tandem mass spectrometry in the multiple reaction monitoring mode and negative ionization. The linearity of the detector response was verified in human plasma over the concentration range 0.100-200 ng mL(-1). The detection limit was 0.03 ng mL(-1) and the quantification limit was 0.100 ng mL(-1). The analytical features of the proposed in-house validated method were satisfactory: precision was