ALPHA-2-ADRENERGIC MECHANISMS IN PREFRONTAL CORTEX ASSOCIATED WITH COGNITIVE DECLINE IN AGED NONHUMAN-PRIMATES
ALPHA-2-ADRENERGIC MECHANISMS IN PREFRONTAL CORTEX ASSOCIATED WITH COGNITIVE DECLINE IN AGED NONHUMAN-PRIMATES
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DOI：
10.1126/science.2999977
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
GOLDMANRAKIC, PS
中科院分区：
文献类型：
--
作者：
ARNSTEN, AFT;GOLDMANRAKIC, PS
该研究提供了证据表明α2-肾上腺素能受体激动剂可乐定通过对α2受体的药物作用改善老年非人灵长类动物表现出的认知缺陷。此外，损伤仅限于背外侧前额皮质的动物的药理学特征表明，该区域可能是可乐定某些有益作用的作用部位。这些结果表明，α-肾上腺素能系统有助于认知功能，并提出了治疗老年人记忆障碍的新策略。
This study provides evidence that the .alpha.2-adrenergic receptor agonist clonidine ameliorates the cognitive deficits exhibited by aged nonhuman primates through drug actions at .alpha.2 receptors. Furthermore, pharmacological profiles in animals with lesions restricted to the dorsolateral prefrontal cortex indicate that this area may be the site of action for some of clonidine''s beneficial effects. These results demonstrate that .alpha.-adrenergic systems contribute to cognitive function and suggest a new strategy for treating memory disorders in aged humans.