Serum vitamin A (retinol) and cancer incidence in Evans County, Georgia.
Serum vitamin A (retinol) and cancer incidence in Evans County, Georgia.
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佐治亚州埃文斯县的血清维生素 A（视黄醇）和癌症发病率。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
C. Hames
中科院分区：
文献类型：
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作者：
J. Kark;A. Smith;B. Switzer;C. Hames
来自佐治亚州埃文斯县的3102个社区样本被跟踪了12-14年。在此期间，根据医疗记录和死亡证明确定了129例记录在案的新癌症病例。只有在受试者被纳入队列研究后至少12个月记录在案的病例才被考虑纳入。病例按照严格的标准分为确定、可能和可能。在1960年至1962年的研究开始时抽取血样，并将血清冷冻。1976年，对85名癌症患者和174名年龄、种族和性别匹配的对照者的血清维生素A（视黄醇）水平进行了测量。氧化铝柱分离后用荧光法测定视黄醇含量。实验模拟了在14-16年的储存过程中血清可能经历的光照、解冻和再冷冻，结果表明视黄醇对这些可能的损害反应相当稳定。与对照组相比，最终患上癌症的人在癌症诊断前至少12个月的平均血清视黄醇水平显著降低。这种关联在所有4个种族和性别群体中都是相同的，尽管男性总体上强于女性，并且在不同的癌症部位和细胞类型上是一致的。使用匹配和回归残差分析来控制考虑的混杂变量：年龄、种族、性别、肥胖、社会阶层和吸烟。
A total community sample of 3,102 individuals from Evans County, Georgia, was followed for 12-14 years. During this period, 129 documented new cases of cancer were ascertained from medical records and death certificates. Cases were considered for inclusion only if documented at least 12 months after subjects were inducted into the cohort study. Cases were classified as definite, probable, and possible by strict criteria. Blood samples were drawn at the beginning of the study in 1960-62 and sera were frozen. Serum vitamin A (retinol) levels were measured in 1976 on the stored sera of 85 cancer patients and for 174 age-, race-, and sex-matched controls. Retinol estimations were performed by a fluorometric method after alumina column separation. Experiments conducted to simulate the exposure to light, thawing, and refreezing that sera may have undergone during the 14-16 years of storage showed retinol to be quite stable in response to these possible insults. As compared to controls, persons that eventually developed cancer had significantly lower mean serum retinol levels at least 12 months before the cancer diagnosis. The association was in the same direction for all 4 race-sex groups, although stronger overall for males than females, and was consistent for the various cancer sites and cell types. Both matched and regression residual analyses were used to control for the confounding variables considered: age, race, sex, obesity, social class, and smoking.