Long-term Results of Endoscopic Sinus Surgery-Oriented Treatment for Chronic Rhinosinusitis With Asthma
Long-term Results of Endoscopic Sinus Surgery-Oriented Treatment for Chronic Rhinosinusitis With Asthma
复制标题
内镜鼻窦手术治疗慢性鼻窦炎伴哮喘的长期结果
DOI：
10.1002/lary.24196
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发表时间：
2014-01-01
期刊：
影响因子：
2.6
通讯作者：
Shi, Jian-Bo
中科院分区：
文献类型：
--
作者：
Chen, Feng-Hong;Zuo, Ke-Jun;Shi, Jian-Bo
目的/假设本研究的目的是评估慢性鼻窦炎（CRS）患者的功能性内窥镜鼻窦手术（FESS）导向的多模式治疗的疗效及其对哮喘的影响。研究设计前瞻性非随机队列。其中25例分别于术后1年和3年进行评价。通过视觉模拟评分、CRS临床控制和内镜Lund-Kennedy评分客观测量来评估CRS。主观哮喘控制测试和哮喘控制水平进行了评估，也通过客观的抗哮喘药物的使用和肺功能tests.ResultsVAS评分的一般症状（8.09 ± 0.87术前）显着改善，在1年（2.94 ± 2.21）和3年（3.77 +/- 2.16）术后（P=.000）。1年和3年之间在这些项目上没有发现差异（P=.463）。术后1年（4.34 +/- 3.09）和3年（5.80 +/- 3.38）的内镜Lund-Kennedy评分明显更好（术前9.33 +/- 2.03，P=.000），1年和3年随访之间无差异（P>.05）。术后哮喘控制水平明显改善（P= 0.025）。结论以FESS为导向的综合治疗可显著改善CRS伴哮喘患者的症状，且疗效持久。哮喘控制水平改善。抗哮喘药物使用和肺功能保持稳定。
Objectives/HypothesisThe aims of this study were to evaluate the efficacy of functional endoscopic sinus surgery (FESS)-oriented multimodality treatment in chronic rhinosinusitis (CRS) patients with asthma and its impact on asthma.Study DesignProspective, nonrandomized cohort.MethodsTwenty-seven CRS patients with asthma who underwent FESS with postoperative topical corticosteroid spray were evaluated preoperatively; 25 of them were evaluated 1 year and 3 years postoperatively. CRS was evaluated by visual analogue scale, clinical control of CRS, and objective measurement endoscopy Lund-Kennedy scores. Asthma was assessed by subjective asthma control test and asthma control level, also by objective antiasthma medication use and pulmonary function tests.ResultsVAS scores of general symptoms (8.090.87 preoperatively) were significantly improved at 1 year (2.942.21) and 3 years (3.77 +/- 2.16) postoperation (P=.000). No difference in these items was found between 1 year and 3 years (P=.463). Endoscopy Lund-Kennedy scores at 1 year (4.34 +/- 3.09) and 3 years (5.80 +/- 3.38) postoperatively were significantly better (9.33 +/- 2.03 preoperatively, P=.000), and there was no difference between 1 year and 3 years of follow-up (P>.05). Significantly, asthma control level improved postoperatively (P=.025). However, antiasthma drug and pulmonary function showed no significant change postoperatively (P>.05).ConclusionsFESS-oriented multimodality treatment improves CRS with asthma significantly and persistently. Asthma control level improved. Antiasthma medication use and pulmonary function remained stable.