Detection of Mobile-Genetic-Element Variation between Colonizing and Infecting Hospital-Associated Methicillin-Resistant Staphylococcus aureus Isolates
Detection of Mobile-Genetic-Element Variation between Colonizing and Infecting Hospital-Associated Methicillin-Resistant Staphylococcus aureus Isolates
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DOI：
10.1128/jcm.05938-11
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发表时间：
2012-03-01
影响因子：
9.4
通讯作者：
Lindsay, Jodi A.
中科院分区：
文献类型：
--
作者：
McCarthy, Alex J.;Breathnach, Aodhan S.;Lindsay, Jodi A.
通过62菌株微阵列进行的全基因组分析显示，40株耐甲氧西林金黄色葡萄球菌（MRSA）菌株CC 22-SCCmecIV之间移动的遗传元件（MGE）上的耐药和毒力基因存在变异，但也显示（i）检测到两种先前未识别的MRSA传播事件，（ii）7/8例患者感染了自身定植分离株的变体。
Whole-genome analysis by 62-strain microarray showed variation in resistance and virulence genes on mobile genetic elements (MGEs) between 40 isolates of methicillin-resistant Staphylococcus aureus (MRSA) strain CC22-SCCmecIV but also showed (i) detection of two previously unrecognized MRSA transmission events and (ii) that 7/8 patients were infected with a variant of their own colonizing isolate.