AN UPDATE ON THE ROLES OF INHIBIN, ACTIVIN, AND FOLLISTATIN AS LOCAL REGULATORS OF FOLLICULOGENESIS
AN UPDATE ON THE ROLES OF INHIBIN, ACTIVIN, AND FOLLISTATIN AS LOCAL REGULATORS OF FOLLICULOGENESIS
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DOI：
10.1095/biolreprod48.1.15
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发表时间：
1993-01-01
影响因子：
3.6
通讯作者：
FINDLAY, JK
中科院分区：
文献类型：
--
作者：
FINDLAY, JK
本文综述了卵泡生成素相关肽卵泡抑素、激活素和卵泡抑素在卵泡生成、黄体化和闭锁中的局部作用。根据体外实验数据，我们得出结论：（a）除了调节FSH分泌的外周作用外，激活素对LH诱导的卵泡膜细胞雄激素产生具有旁分泌作用，（B）激活素对LH诱导的卵泡膜细胞雄激素产生具有负旁分泌作用;（c）激活素单独或与FSH一起对颗粒细胞具有自分泌作用，促进卵泡发生的窦前和早期窦阶段的分化，并防止窦卵泡发育后期的过早黄素化，总体上导致促进和维持卵泡的卵泡发生状态;和（d）卵泡抑素调节颗粒细胞功能，有利于黄体化或闭锁，并且其作用机制包括通过其结合特性和通过卵泡抑素对颗粒细胞的孕酮代谢的直接作用来中和激活素的作用。激活素在获得腔前卵泡颗粒细胞对FSH的反应性中的作用的假说被提出。
The local actions of the inhibin-related peptides inhibin, activin, and follistatin in folliculogenesis, luteinization and atresia are reviewed. On the basis of in vitro data, it is concluded that (a) inhibin has a paracrine action positively regulating LH-induced androgen production by theca cells in addition to a peripheral role regulating FSH secretion; (b) activin has a negative paracrine action on LH-induced androgen production by theca cells; (c) activin, either alone or with FSH, has an autocrine action on granulosa cells, promoting differentiation during the preantral and early antral stages of folliculogenesis and preventing premature luteinization in the later stages of antral follicle development, leading overall to promotion and maintenance of the folliculogenic state of the follicle; and (d) follistatin modulates granulosa cell function in favor of luteinization or atresia, and its mechanism of action involves neutralizing the actions of activin by its binding properties and by a direct action of follistatin on progesterone metabolism by granulosa cells. A hypothesis for a role of activin in the acquisition of responsiveness of granulosa cells of preantral follicles to FSH is proposed.