PROGNOSTIC FACTORS IN POLYMYOSITIS - DERMATOMYOSITIS - A COMPUTER-ASSISTED ANALYSIS OF 92 CASES
PROGNOSTIC FACTORS IN POLYMYOSITIS - DERMATOMYOSITIS - A COMPUTER-ASSISTED ANALYSIS OF 92 CASES
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DOI：
10.1002/art.1780280303
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
ZLOTNICK, A
中科院分区：
文献类型：
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作者：
BENBASSAT, J;GEFEL, D;ZLOTNICK, A
对1956-1976年间以色列医院收治的所有多发性肌炎/皮肌炎（PM/DM）患者进行了鉴定。回顾性分析了92例PM/DM的诊断（确诊46例，可能26例，可能20例）。病程中最常见的主诉和体格表现为肌肉无力（86例）、皮疹（53例）、关节炎或关节痛（39例）和吞咽困难（35例）。有资料的患者中有64%血清醛缩酶水平升高；92%的患者肌电图异常，60.9%的患者肌肉组织病理符合PM/DM。恶性肿瘤13例。恶性肿瘤、缺血性心脏病和肺部并发症是最常见的死亡原因。精算生存曲线具有异质性，诊断后1年死亡率加快，随后7年死亡率减慢。独立的不利预后体征为：无法诱导缓解、白细胞增多、发热、年龄较大、病程较短和吞咽困难。
An effort was made to identify all patients with polymyositis/dermatomyositis (PM/DM) admitted to hospitals in Israel from 1956-1976. The diagnosis of PM/DM was retrospectively reviewed in 92 (46 definite, 26 probable and 20 possible) cases. The most common complaints and physical findings in the course of the disease were muscle weakness (86 patients), rash (53 patients), arthritis or arthralgia (39 patients), and dysphagia (35 patients). Elevated serum aldolase levels were found in 64% of the patients for whom data were available; 92% had abnormal electromyogram results, and 60.9% had muscle histopathology consistent with PM/DM. Malignancy was diagnosed in 13 patients. Malignancy, ischemic heart disease and pulmonary complications were the most common causes of death. The actuarial survival curve was heterogeneous, with an accelerated mortality during the 1st yr after diagnosis and a slower mortality during the following 7 yr. Independent unfavorable prognostic signs were: failure to induce remission, leukocytosis, fever, older age, a shorter disease history and dysphagia.