Pre-existing T Cell Memory to Novel Pathogens.
Pre-existing T Cell Memory to Novel Pathogens.
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DOI：
10.4049/immunohorizons.2200003
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发表时间：
2023-07-01
期刊：
影响因子：
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通讯作者：
Su LF
中科院分区：
文献类型：
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作者：
Afroz S;Bartolo L;Su LF
免疫学经验导致特定的T和B细胞记忆的发展，这为宿主准备迎接后来的病原体重新攻击。目前，免疫记忆最好的理解是一个线性过程，即记忆反应是由相同的病原体产生的，并针对相同的病原体。然而，许多研究已经确定了针对未接触过的病原体的记忆细胞。“预先存在的记忆”是如何形成并影响感染结果的，目前尚不清楚。在这篇综述中，我们讨论了小鼠和人类基线T细胞谱系的组成差异，影响预先存在的免疫状态的因素，以及关于它们功能意义的最新文献。我们总结了当前关于预先存在的T细胞在动态平衡和扰动中的作用及其对健康和疾病的影响的知识。
Immunological experiences lead to the development of specific T and B cell memory, which readies the host for a later pathogen rechallenge. Currently, immunological memory is best understood as a linear process whereby memory responses are generated by and directed against the same pathogen. However, numerous studies have identified memory cells that target pathogens in unexposed individuals. How “pre-existing memory” forms and impacts the outcome of infection remains unclear. In this review, we discuss differences in the composition of baseline T cell repertoire in mice and humans, factors that influence pre-existing immune states, and recent literature on their functional significance. We summarize current knowledge on the roles of pre-existing T cells in homeostasis and perturbation and their impacts on health and disease.