C-reactive protein and the risk of incident colorectal cancer
C-reactive protein and the risk of incident colorectal cancer
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DOI：
10.1001/jama.291.5.585
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发表时间：
2004-02-04
影响因子：
120.7
通讯作者：
Helzlsouer, KJ
中科院分区：
文献类型：
--
作者：
Erlinger, TP;Platz, EA;Helzlsouer, KJ
炎症可能在结直肠癌的发病机制中发挥作用;然而，在平均风险人群中支持这一假设的流行病学证据很少。目的确定与C反应蛋白（CRP）基线血浆浓度升高相关的结肠癌和直肠癌发病风险。设计、设置和参与者前瞻性，对22887名成年人（年龄>18岁，华盛顿县，马里兰州，居民）进行的巢式病例对照研究，于1989年5月至10月入组，随访至2000年12月。通过与华盛顿县和马里兰州癌症登记处的联系，共确定了172例结肠直肠癌病例。每个病例组中最多选择2个对照组（n=342），并按年龄、性别、种族和抽血日期进行匹配。主要结果测量结肠癌和直肠癌发病率的比值比（OR）。最高浓度出现在随后发展为结肠癌的人与匹配的对照组（CRP中位数，2.69 vs 1.97 mg/L; P
Context Inflammation may play a role in the pathogenesis of colorectal cancer; however, epidemiological evidence supporting this hypothesis in average-risk persons is sparse.Objective To determine the risk of incident colon and rectal cancer associated with elevated baseline plasma concentrations of C-reactive protein (CRP).Design, Setting, and Participants Prospective, nested case-control study of a cohort of 22887 adults (>18 years and Washington County, Maryland, residents) enrolled between May and October 1989 and followed up through December 2000. A total of 172 colorectal cancer cases were identified through linkage with the Washington County and Maryland State Cancer registries. Up to 2 controls (n=342) were selected from the cohort for each case and matched by age, sex, race, and date of blood draw.Main Outcome Measure Odds ratio (OR) of incident colon and rectal cancer.Results Plasma CRP concentrations were higher among all colorectal cases combined than controls (median CRP, 2.44 vs 1.94 mg/L; P=.01). The highest concentration was found in persons who subsequently developed colon cancer vs matched controls (median CRP, 2.69 vs 1.97 mg/L; P