Nickel-Catalyzed Decarbonylative Coupling of Aryl Esters and Arylboronic Acids
Nickel-Catalyzed Decarbonylative Coupling of Aryl Esters and Arylboronic Acids
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DOI：
10.1002/ejoc.201500630
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发表时间：
2015-09-01
影响因子：
2.8
通讯作者：
Love, Jennifer A.
中科院分区：
文献类型：
--
作者：
LaBerge, Nicole A.;Love, Jennifer A.
通过由 Ni(cod)(2) 和 PCy3 组成的经济型催化剂体系催化的 Suzuki-Miyaura 型脱羰交叉偶联，将芳基和杂芳基酯与硼酸偶联，可以得到各种官能化联芳基化合物。该方法能够耐受多种官能团，并且为目前工业中使用的钯催化获得此类双（杂）芳基提供了一种有吸引力的替代方案，但也揭示了交叉偶联化学中与酯的镍催化相关的挑战。
A variety of functionalized biaryls can be accessed by coupling aryl and heteroaryl esters with boronic acids in Suzuki-Miyaura-type decarbonylative cross-coupling catalyzed by an affordable catalyst system composed of Ni(cod)(2) and PCy3. The methodology is tolerant of a variety of functional groups and presents an attractive alternative to the use of palladium catalysis currently used in industry to acquire such bis(hetero)aryls, but also reveals challenges associated with nickel catalysis of esters in cross-coupling chemistry.