Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus
Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus
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DOI：
10.1073/pnas.97.20.11032
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发表时间：
2000-09-26
影响因子：
11.1
通讯作者：
Abrous, DN
中科院分区：
文献类型：
--
作者：
Lemaire, V;Koehl, M;Abrous, DN
产前压力等早期经历显着影响大脑的发育和行为的组织。特别是，产前压力会损害记忆过程，但这种影响的机制尚不清楚。海马颗粒神经元在一生中都会产生，并参与海马依赖性学习。这里。我们报告说，大鼠的产前应激导致齿状回神经发生的寿命缩短，并导致海马相关的空间任务受损。产前应激阻碍了学习诱发的神经发生的增加。这些数据强化了病理生理学假设，提出衰老过程中精神病理脆弱性的早期神经发育起源。
Early experiences such as prenatal stress significantly influence the development of the brain and the organization of behavior. In particular, prenatal stress impairs memory processes but the mechanism for this effect is not known. Hippocampal granule neurons are generated throughout life and are involved in hippocampal-dependent learning. Here. we report that prenatal stress in rats induced lifespan reduction of neurogenesis in the dentate gyrus and produced impairment in hippocampal-related spatial tasks. Prenatal stress blocked the increase of learning-induced neurogenesis. These data strengthen pathophysiological hypotheses that propose an early neurodevelopmental origin for psychopathological vulnerabilities in aging.