The frontopolar cortex mediates event knowledge complexity: a parametric functional MRI study.
The frontopolar cortex mediates event knowledge complexity: a parametric functional MRI study.
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DOI：
10.1097/wnr.0b013e32832e7ea5
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发表时间：
2009-08-05
期刊：
影响因子：
1.7
通讯作者：
Grafman J
中科院分区：
文献类型：
--
作者：
Krueger F;Spampinato MV;Barbey AK;Huey ED;Morland T;Grafman J
事件知识是根据目标来组织的，这些目标使得能够选择特定的事件序列来组织日常生活活动。尽管内侧前额叶皮层代表事件知识，但人们对其在调节事件知识复杂性中的作用知之甚少。我们使用功能性 MRI 来研究大脑激活模式，同时健康志愿者参与评估根据规范数据选择的日常生活活动的复杂性（即事件数量）的任务。在左额顶叶网络中，我们将内侧额极皮层隔离为唯一显示血氧水平依赖性信号变化与事件知识复杂性变化之间存在线性关系的区域。我们的结果表明了内侧额极皮层在维护构建和执行复杂行为所需的事件知识方面的重要性。
Event knowledge is organized on the basis of goals that enable the selection of specific event sequences to organize everyday life activities. Although the medial prefrontal cortex represents event knowledge, little is known about its role in mediating event knowledge complexity. We used functional MRI to investigate the patterns of brain activation while healthy volunteers were engaged in the task of evaluating the complexity (i.e. numbers of events) of daily life activities selected on the basis of normative data. Within a left frontoparietal network, we isolated the medial frontopolar cortex as the only region that showed a linear relationship between changes in the blood oxygen level-dependent signal and changes in event knowledge complexity. Our results specify the importance of the medial frontopolar cortex in subserving event knowledge that is required to build and execute complex behavior.