Hematopoietic stem cells and the aging hematopoietic system
Hematopoietic stem cells and the aging hematopoietic system
复制标题
DOI：
10.1053/j.seminhematol.2008.07.010
复制
发表时间：
2008-10-01
影响因子：
3.6
通讯作者：
Rossi, Derrick J.
中科院分区：
文献类型：
--
作者：
Gazit, Roi;Weissman, Irving L.;Rossi, Derrick J.
造血系统与年龄相关的病理生理变化的病因包括贫血发作、适应性免疫能力下降和骨髓疾病的发生，其原因是正常稳态控制的丧失。由于成人的组织和器官稳态主要由干细胞和祖细胞的活性介导，因此有人提出，伴随造血系统衰老的失衡可能源于造血干细胞（HSC）和祖细胞的普遍性和/或功能能力的改变。在这篇综述中，我们研究了干细胞在造血系统衰老中的作用的证据，并重点关注了导致干细胞衰老的机制。
The etiology of the age-associated pathophysiological changes of the hematopoietic system including the onset of anemia, diminished adaptive immune competence, and myelogenous disease development are underwritten by the loss of normal homeostatic control. As tissue and organ homeostasis in adults is primarily mediated by the activity of stem and progenitor cells, it has been suggested that the imbalances accompanying aging of the hematopoietic system may stem from alterations in the prevalence and/or functional capacity of hematopoietic stem cells (HSCs) and progenitors. In this review, we examine evidence implicating a role for stem cells in the aging of the hematopoietic system, and focus on the mechanisms suggested to contribute to stem cell aging.