Preparation and properties of Nalpha-9-fluorenylmethyloxycarbonylamino acids bearing tert.-butyl side chain protection.
Preparation and properties of Nalpha-9-fluorenylmethyloxycarbonylamino acids bearing tert.-butyl side chain protection.
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带有叔丁基侧链保护的Nα-9-芴基甲氧基羰基氨基酸的制备和性能。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
J. D. Haug
中科院分区：
文献类型：
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作者：
C.;Michinori Waki;Mushtaq Ahmad;Johannes Meienhofer;Edwin O. Lundell;J. D. Haug
The preparation is described by several Nalpha-9-fluorenylmethyloxycarbonylamino acids and derivatives bearing tert.-butyl type side-chain protection of amine, carboxyl, guanido, hydroxyl, imidazol, and sulfhydryl functionalities. Physicochemical properties of these compounds have been determined. Cleavage of the Fmoc group by various amines appears to depend on the base strength and steric hindrance. Premature deblocking of Fmoc group by amine on solid support is very slow and may be negligible under the conditions of solid-phase synthesis.
