The TLR9 agonist CpG fails to enhance the acquisition of Plasmodium falciparum-specific memory B cells in semi-immune adults in Mali.
The TLR9 agonist CpG fails to enhance the acquisition of Plasmodium falciparum-specific memory B cells in semi-immune adults in Mali.
复制标题
TLR9 激动剂 CpG 未能增强马里半免疫成人中恶性疟原虫特异性记忆 B 细胞的获得。
DOI：
10.1016/j.vaccine.2009.08.023
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发表时间：
2009
期刊：
影响因子：
5.5
通讯作者：
Miller,Lou
中科院分区：
文献类型：
--
作者：
Traore,Boubacar;Koné,Younoussou;Doumbo,Safiatou;Doumtabé,Didier;Traoré,Abdramane;Crompton,PeterD;Mircetic,Marko;Huang,Chiung-Yu;Kayentao,Kassoum;Dicko,Alassane;Sagara,Issaka;Ellis,RuthD;Miura,Kazutoyo;Guindo,Agnes;Miller,Lou
Antibodies play a key role in controlling blood stage malaria infections, and an effective blood stage malaria vaccine will likely require that it induce vaccine-specific memory B cells (MBCs). Our previous studies showed that the addition of the TLR9 agonist CpG to Plasmodium falciparum protein subunit vaccines greatly increased their efficacy in inducing MBCs in nonimmune U.S. volunteers. Here we show that in contrast the same CpG-containing malaria vaccine did not enhance the acquisition of MBCs in semi-immune adults living in Mali. Understanding the molecular basis of this apparent refractoriness to TLR9 agonist will be of significant interest in vaccine design.
