Occipital Artery Function during the Development of 2-Kidney, 1-Clip Hypertension in Rats.
Occipital Artery Function during the Development of 2-Kidney, 1-Clip Hypertension in Rats.
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DOI：
10.1155/2014/659617
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发表时间：
2014
影响因子：
1.3
通讯作者：
Lewis SJ
中科院分区：
文献类型：
--
作者：
Chelko SP;Schmiedt CW;Lewis TH;Robertson TP;Lewis SJ
本研究比较了血管紧张素II（AII）、精氨酸加压素（AVP）和5-羟色胺（5-HT）对假手术（SHAM）和2肾1夹（2K-1C）高血压大鼠枕动脉（OAs）的收缩反应。分离OA并将其分成近端段（更靠近颈总动脉）和远端段（更靠近结状神经节），并分别安装在肌电描记器上。在第9天，2K-1C大鼠的平均动脉血压，心率和血浆肾素浓度高于SHAM大鼠。与SHAM大鼠相比，2K-1C大鼠OA近端和远端对AII的收缩反应均明显减弱。AVP引起的反应在SHAM大鼠OA的远侧段明显大于近侧段，AVP在2K-1C大鼠OA段引起类似的反应。SHAM和2K-1C大鼠的近、远节段对5-HT的反应相似。这些结果表明，在2K-1C大鼠中持续暴露于循环AII和AVP降低了AII的收缩功效，但不降低AVP或5-HT的收缩功效。对AII的反应性降低可能改变OAs在体内的生理状态。
This study compared the contractile responses elicited by angiotensin II (AII), arginine vasopressin (AVP), and 5-hydroxytryptamine (5-HT) in isolated occipital arteries (OAs) from sham-operated (SHAM) and 2-kidney, 1-clip (2K-1C) hypertensive rats. OAs were isolated and bisected into proximal segments (closer to the common carotid artery) and distal segments (closer to the nodose ganglion) and mounted separately on myographs. On day 9, 2K-1C rats had higher mean arterial blood pressures, heart rates, and plasma renin concentrations than SHAM rats. The contractile responses to AII were markedly diminished in both proximal and distal segments of OAs from 2K-1C rats as compared to those from SHAM rats. The responses elicited by AVP were substantially greater in distal than in proximal segments of OAs from SHAM rats and that AVP elicited similar responses in OA segments from 2K-1C rats. The responses elicited by 5-HT were similar in proximal and distal segments from SHAM and 2K-1C rats. These results demonstrate that continued exposure to circulating AII and AVP in 2K-1C rats reduces the contractile efficacy of AII but not AVP or 5-HT. The diminished responsiveness to AII may alter the physiological status of OAs in vivo.