Genome-Wide Association Study in German Patients With Attention Deficit/Hyperactivity Disorder
Genome-Wide Association Study in German Patients With Attention Deficit/Hyperactivity Disorder
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DOI：
10.1002/ajmg.b.31246
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发表时间：
2011-12-01
影响因子：
2.8
通讯作者：
Hebebrand, Johannes
中科院分区：
文献类型：
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作者：
Hinney, Anke;Scherag, Andre;Hebebrand, Johannes
注意缺陷多动障碍（ADHD）的遗传率约为0.8。尽管有几次更大规模的尝试，全基因组关联研究（GWAS）并没有导致显著结果的鉴定。我们对495名德国年轻ADHD患者（根据DSM-IV标准；Human660W-Quadv1; Illumina, San Diego， CA）和1300名基于人群的成人对照（HumanHap550v3; Illumina）进行了GWAS。一些p值最低的单核苷酸多态性（snp）附近的基因（最佳p值为8.38 × 10(-7)）与ADHD有潜在的相关性（如谷氨酸受体，代谢5基因，GRM5）。质量控制后，30个p值最低的独立snp (p值
The heritability of attention deficit hyperactivity disorder (ADHD) is approximately 0.8. Despite several larger scale attempts, genome-wide association studies (GWAS) have not led to the identification of significant results. We performed a GWAS based on 495 German young patients with ADHD (according to DSM-IV criteria; Human660W-Quadv1; Illumina, San Diego, CA) and on 1,300 population-based adult controls (HumanHap550v3; Illumina). Some genes neighboring the single nucleotide polymorphisms (SNPs) with the lowest P-values (best P-value: 8.38 x 10(-7)) have potential relevance for ADHD (e. g., glutamate receptor, metabotropic 5 gene, GRM5). After quality control, the 30 independent SNPs with the lowest P-values (P-values