A Method for Characterization of Tissue Elastic Properties Combining Ultrasonic Computed Tomography With Elastography
A Method for Characterization of Tissue Elastic Properties Combining Ultrasonic Computed Tomography With Elastography
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DOI：
10.7863/jum.2010.29.3.387
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发表时间：
2010-03-01
影响因子：
2.3
通讯作者：
Azhari, Haim
中科院分区：
文献类型：
--
作者：
Glozman, Tanya;Azhari, Haim
客观的。各种疾病与软组织局部机械性能变化之间的相关性早已为人所知。在过去的 20 年里，人们越来越多地研究利用超声弹性成像来表征生物组织的机械特性。然而，大多数这些工作仅基于一种类型的波（纵向波或剪切波）的表征。这项工作的目标是设计一种基于超声的综合成像方法，能够通过结合背散射弹性成像和透射超声计算机断层扫描来测量弹性参数。方法。我们建议的技术提供了纵向波速和剪切波速的测量。这使得能够无创地计算多个组织弹性参数，例如杨氏模量和剪切模量、泊松比，以及更重要的是体积模量，其确定需要波速。检查了四种不同的模型类型：基于琼脂明胶的模型和猪脂肪组织、火鸡乳房组织和牛肝组织体外样本。估算了杨氏模量、剪切模量和泊松比的值，并且与文献中公布的值一致。结果。体模+/-SD的平均体积模量值分别为2.83+/-0.001、2.25+/-0.01、2.48+/-0.01和2.53+/-0.02GPa。发现不同体模的体积模量值存在统计学显着差异 (P < .001)。结论。体积模量适用于区分不同的组织类型。获得的结果表明使用综合超声成像技术进行无创定量组织表征的可行性。
Objective. The correlation between various diseases and the change in the local mechanical properties of soft tissues has been long known. Over the past 20 years, there have been increasing research efforts to characterize mechanical properties of biological tissues using ultrasonic elastography. However, most of these works were based on characterization of only 1 type of waves (longitudinal or shear). The goal of this work was to devise a comprehensive ultrasound-based imaging method capable of measuring elastic parameters by combining both backscattered elastography and through-transmitted ultrasonic computed tomography. Methods. Our suggested technique provides measurements of both longitudinal and shear wave velocities. This enables the noninvasive computation of several tissue elasticity parameters such as Young's and shear moduli, Poisson's ratio, and, more importantly, the bulk modulus, the determination of which requires both wave velocities. Four different phantom types were examined: agar-gelatin-based phantoms and porcine fat tissue, turkey breast tissue, and bovine liver tissue in vitro specimens. The values of Young's modulus, the shear modulus, and Poisson's ratio were estimated and were consistent with values published in the literature. Results. The average bulk modulus values of the phantoms +/- SD were 2.83 +/- 0.001, 2.25 +/- 0.01, 2.48 +/- 0.01, and 2.53 +/- 0.02 GPa, respectively. A statistically significant difference (P < .001) in the values of the bulk modulus of the different phantoms was found. Conclusions. The bulk modulus is suitable for differentiation between different tissue types. The obtained results show the feasibility of using a comprehensive ultrasonic imaging technique for noninvasive quantitative tissue characterization.