Serotonin and ethanol preference.
Serotonin and ethanol preference.
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血清素和乙醇偏好。
DOI：
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
T. Li
中科院分区：
文献类型：
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作者：
W. Mcbride;J. Murphy;L. Lumeng;T. Li
本章汇集了表明5-羟色胺（5-HT）参与乙醇偏好的证据，这些数据主要来自选择性繁殖的酒精偏好系和非酒精偏好系。虽然几个实验室已经建立了每天消耗大量乙醇的啮齿动物系，但迄今为止，只有一种啮齿动物系满足酒精中毒动物模型的所有标准，适合研究乙醇偏好的生物学基础。这是酒精偏好大鼠的P线：(1)每天每公斤体重自由消耗5-9克乙醇；（二）饮酒过量，使血液酒精浓度达到令人陶醉的；（三）从事获取酒类的工作；(4)因乙醇对中枢神经系统的药理作用而自行服用乙醇；(5)对酒精产生慢性耐受和依赖，可自由选择饮酒。相对于不嗜酒大鼠的NP系，嗜酒大鼠在几个中枢神经系统区域的5-羟色胺水平较低，包括一些，如伏隔核、下丘脑和额叶皮质，这些区域与大脑奖赏回路有关。此外，急性和慢性乙醇给药对P大鼠中缝背核至伏隔核的5-HT通路均有影响。药理学研究表明，氟西汀（一种5 -羟色胺摄取抑制剂）减少了P大鼠的口服或灌胃自我给药酒精。此外，施用5-HT1B激动剂也减少了P大鼠口服乙醇的摄入量。假设从中缝背核到伏隔核的5 -羟色胺能通路参与了酒精在大鼠P系中的强化作用。
This chapter brings together evidence indicating the involvement of serotonin (5-HT) in ethanol preference using data mainly obtained from selectively bred alcohol-preferring and alcohol-nonpreferring lines of rodents. Although several laboratories have established rodent lines that will consume large quantities of ethanol daily, only one line thus far has been established that satisfied all the criteria for an animal model of alcoholism and that would be suitable for studying the biological basis of ethanol preference. This is the P line of alcohol-preferring rats that: (1) freely consumes 5-9 g ethanol/kg body wt/day; (2) drinks sufficient alcohol to produce intoxicating blood alcohol concentrations; (3) works to obtain alcohol; (4) self-administers ethanol for its CNS pharmacological effects; and (5) develops chronic tolerance to and dependence on alcohol with free-choice drinking. Relative to the NP line of alcohol-nonpreferring rats, the P rat has lower 5-HT levels in several CNS regions, including some, such as the nucleus accumbens, hypothalamus, and frontal cortex, which are involved in the brain reward circuitry. Furthermore, both acute and chronic ethanol administration have effects on the 5-HT pathway from the dorsal raphe nucleus to the nucleus accumbens in the P rat. Pharmacological studies have demonstrated that fluoxetine, a serotonin uptake inhibitor, reduced the oral consumption or intragastric self-administration of alcohol in the P rats. In addition, administration of a 5-HT1B agonist also attenuated the oral intake of ethanol by P rats. It is hypothesized that the serotonergic pathway from the dorsal raphe nucleus to the nucleus accumbens is involved in the reinforcing actions of alcohol in the P line of rats.
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N/Nih 异种大鼠的酒精偏好和区域脑单胺含量。
DOI：
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发表时间：
1987
期刊：
Alcohol and drug research
影响因子：
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作者：
Murphy,JM;McBride,WJ;Lumeng,L;Li,TK
通讯作者：
Li,TK
测定大鼠额叶皮质中 5-HT 1A 和 5-HT 1B 受体亚型的选择性和非选择性化合物。
DOI：
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发表时间：
1984
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Sills,MA;Wolfe,BB;Frazer,A
通讯作者：
Frazer,A
通过偏好乙醇和不偏好乙醇的大鼠系进行胃内自我输注乙醇。
DOI：
10.1126/science.6539502
发表时间：
1984
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Waller,MB;McBride,WJ;Gatto,GJ;Lumeng,L;Li,TK
通讯作者：
Li,TK
单胺摄取抑制剂可减少嗜酒 (P) 大鼠的乙醇摄入量。
DOI：
10.1016/0741-8329(85)90073-4
发表时间：
1985
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Murphy,JM;Waller,MB;Gatto,GJ;McBride,WJ;Lumeng,L;Li,TK
通讯作者：
Li,TK