Intestinal permeability in physiological and pathological conditions: major determinants and assessment modalities
Intestinal permeability in physiological and pathological conditions: major determinants and assessment modalities
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DOI：
10.26355/eurrev_201901_16894
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发表时间：
2019-01-01
影响因子：
3.3
通讯作者：
Scaldaferri, F.
中科院分区：
文献类型：
--
作者：
Graziani, C.;Talocco, C.;Scaldaferri, F.
肠通透性是指肠腔和肠粘膜之间能够进行溶质和液体交换的性质。许多因素可能对其调节产生重大影响，包括肠道微生物群、粘液层、上皮细胞完整性、上皮连接、免疫反应、肠道脉管系统和肠道运动。这些因素中的任何变化都可能影响肠道内稳态和肠道通透性。健康状况与正常的肠通透性相关，而几种肠和肠外疾病，如炎症性肠病、肠易激综合征、非酒精性脂肪肝等，本文综述了影响肠道通透性的因素，并介绍了在临床和研究中测量肠道通透性的方法设置.
Intestinal permeability is the property that allows solute and fluid exchange between intestinal lumen and intestinal mucosa. Many factors could have major impact on its regulation, including gut microbiota, mucus layer, epithelial cell integrity, epithelial junction, immune responses, intestinal vasculature, and intestinal motility. Any change among these factors could have an impact on intestinal homeostasis and gut permeability. Healthy condition is associated to normal intestinal permeability whereas several intestinal and extra intestinal disease, like inflammatory bowel disease, irritable bowel syndrome, non-alcoholic fatty liver disease among others, are associated to increased intestinal permeability.This review aims to synthesize determinants on intestinal permeability and to report methodologies useful to the measurement of intestinal permeability in clinical practice as well as in research settings.