The effect of erythroid hyperplasia on iron balance.
The effect of erythroid hyperplasia on iron balance.
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DOI：
10.1182/blood.v71.4.1124.1124
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发表时间：
1988-04
期刊：
影响因子：
20.3
通讯作者：
P. Pootrakul;K. Kitcharoen;P. Yansukon;P. Wasi;S. Fucharoen;P. Charoenlarp;G. Brittenham;M. Pippard;C. Finch
中科院分区：
文献类型：
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作者：
P. Pootrakul;K. Kitcharoen;P. Yansukon;P. Wasi;S. Fucharoen;P. Charoenlarp;G. Brittenham;M. Pippard;C. Finch
对 8 名正常受试者和 32 名贫血受试者进行了红细胞生成和铁平衡测量。后者包括 12 名红细胞生成无效（β-地中海贫血/血红蛋白 E）的个体、13 名红细胞生成无效和溶血性贫血（血红蛋白 H）的受试者以及 7 名患有溶血性贫血（遗传性球形红细胞增多症）的受试者。每组内红细胞生成程度和放射性铁吸收之间存在一致的关系。尽管红细胞生成对铁吸收的影响在两个地中海贫血组中的程度相似，但对遗传性球形红细胞增多症的影响要小得多。地中海贫血中铁储备的吸收与铁蛋白或磁化率 (SQUID) 测量结果一致，但在遗传性球形红细胞增多症中，吸收与铁蛋白之间存在差异。结论是，尽管红细胞生成增加与铁吸收增加相关，但与红细胞分解相关的一些其他因素更直接地导致地中海贫血中的铁正平衡。
Measurements of erythropoiesis and iron balance were made in eight normal and 32 anemic subjects. The latter consisted of 12 individuals with ineffective erythropoiesis (beta-thalassemia/hemoglobin E), 13 subjects with ineffective erythropoiesis and hemolytic anemia (hemoglobin H), and seven subjects with hemolytic anemia (hereditary spherocytosis). A consistent relationship within each group existed between the degree of erythropoiesis and radioiron absorption. Although the effect of erythropoiesis on iron absorption was of similar magnitude in the two thalassemia groups, the effect in hereditary spherocytosis was much less. There was agreement between absorption and ferritin or magnetic susceptibility (SQUID) measurements of iron stores in thalassemia, but in hereditary spherocytosis a discrepancy existed between absorption and ferritin. It is concluded that, although increased erythropoiesis is associated with increased iron absorption, some additional factor associated with red cell breakdown is more directly responsible for the positive iron balance in thalassemia.