Intraventricular ghrelin activates oxytocin neurons: implications in feeding behavior
Intraventricular ghrelin activates oxytocin neurons: implications in feeding behavior
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DOI：
10.1097/wnr.0b013e328058684e
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发表时间：
2007-03-26
期刊：
影响因子：
1.7
通讯作者：
Levine, Allen S.
中科院分区：
文献类型：
--
作者：
Olszewski, Pawel K.;Bomberg, Eric M.;Levine, Allen S.
胃饥饿素影响行为和生理反应，如进食或下丘脑轴的活动。胃饥饿素受体分布在中枢神经内分泌控制部位，包括下丘脑室旁核，这表明胃饥饿素与多种神经肽能系统相互作用是其作用的基础。我们报道脑室内胃饥饿素增加脑室旁核的磁和旁细胞部分催产素神经元的c-Fos免疫反应性。在激活催产素神经元的剂量下，胃饥饿素的促氧反应可以通过选择性催产素受体拮抗剂的预处理进一步提高。我们的数据表明，催产素可能负责调解由胃饥饿素诱导的一些影响。催产素系统活动的改变可能会改变其中的一些效果。
Ghrelin affects behavioral and physiological responses, such as feeding or the activity of the HPA axis. Distribution of its receptor in central sites involved in neuroendocrine control, including the hypothalamic paraventricular nucleus, indicates that interplay with multiple neuropeptidergic systems underlies ghrelin's actions. We report that intracerebroventricular ghrelin increases c-Fos immunoreactivity of oxytocin neurons in magno and parvocellular portions of the paraventricular nucleus. The orexigenic response to ghrelin administered at the dose that activates oxytocin neurons can be further elevated by pretreatment with a selective oxytocin receptor antagonist. Our data suggest that oxytocin may be responsible for the mediation of some effects induced by ghrelin. Modifications in the activity of the oxytocin system may alter some of these effects.